Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/127963
Title: | Collective cell durotaxis emerges from long-range intercellular force transmission |
Author: | Sunyer, Raimon Conte, Vito Escribano, Jorge Elosegui Artola, Alberto Labernadie, Anna Valon, Léo Navajas Navarro, Daniel García Aznar, José Manuel Muñoz, José J. Roca-Cusachs Soulere, Pere Trepat Guixer, Xavier |
Keywords: | Cèl·lules Cèl·lules canceroses Càncer Cells Cancer cells Cancer |
Issue Date: | 9-Sep-2016 |
Publisher: | American Association for the Advancement of Science |
Abstract: | The ability of cells to follow gradients of extracellular matrix stiffness-durotaxis-has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1126/science.aaf7119 |
It is part of: | Science, 2016, vol. 353, num. 6304, p. 1157-1161 |
URI: | http://hdl.handle.net/2445/127963 |
Related resource: | https://doi.org/10.1126/science.aaf7119 |
ISSN: | 0036-8075 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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