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https://hdl.handle.net/2445/128198| Title: | Synthesis of a-chlorolactams by cyanoborohydride-mediated radical cyclization of trichloroacetamides |
| Author: | Coussanes, Guilhem Jakobi, Harald Lindell, Stephen Bonjoch i Sesé, Josep |
| Keywords: | Lactames Herbicides Radicals (Química) Síntesi orgànica Lactams Herbicides Radicals (Chemistry) Organic synthesis |
| Issue Date: | 16-May-2018 |
| Publisher: | Wiley-VCH |
| Abstract: | A cyanoborohydride-promoted radical cyclization methodology has been developed to access α-chlorolactams in a simple and efficient way, using NaBH3CN and trichloroacetamides easily available from allylic and homoallylic secondary amines. This methodology allowed the synthesis of a library of αchlorolactams (mono and bicyclic), which were tested for herbicidal activity, trans-3-chloro-4-methyl-1-(3-trifluoromethyl)phenyl-2-pyrrolidinone being the most active. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1002/chem.201800210 |
| It is part of: | Chemistry-A European Journal, 2018, vol. 24, num. 32, p. 8151-8156 |
| URI: | https://hdl.handle.net/2445/128198 |
| Related resource: | https://doi.org/10.1002/chem.201800210 |
| ISSN: | 0947-6539 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 683223.pdf | 383.6 kB | Adobe PDF | View/Open |
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