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http://hdl.handle.net/2445/128365| Title: | Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones |
| Author: | Diaba, Faïza Montiel Achong, Juan Andrés Serban, Georgeta Bonjoch i Sesé, Josep |
| Keywords: | Cetones Amines Síntesi orgànica Reaccions químiques Ketones Amines Organic synthesis Chemical reactions |
| Issue Date: | 21-Jan-2015 |
| Publisher: | American Chemical Society |
| Abstract: | An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-type reaction of trichloroacetamides promoted by enamines (generated in situ from ketones) as counter-reagents. The methodology was applied to the synthesis of compounds embodying the 6-azabicyclo[3.2.1]octane framework. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.5b01832 |
| It is part of: | Organic Letters, 2015, vol. 2015, num. 17, p. 3860-3863 |
| URI: | http://hdl.handle.net/2445/128365 |
| Related resource: | https://doi.org/10.1021/acs.orglett.5b01832 |
| ISSN: | 1523-7060 |
| Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 654621.pdf | 784.7 kB | Adobe PDF | View/Open |
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