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Title: Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma
Author: Tejera Vaquerizo, Antonio
Nagore, Eduardo
Puig i Sardà, Susana
Robert, Caroline
Saiag, Philippe
Martín-Cuevas, Paula
Gallego, Elena
Herrera Acosta, Enrique
Aguilera, José
Malvehy, J. (Josep)
Carrera Álvarez, Cristina
Cavalcanti, Andrea
Rull, Ramón
Vilalta Solsona, Antonio
Lannoy, Emilie
Boutros, Celine
Benannoune, Naima
Tomasic, Gorana
Aegerte, Philippe
Vidal i Sicart, Sergi
Palou, Josep
Alós i Hernández, Llúcia
Requena, Celia
Traves, Víctor
Pla, Ángel
Bolumar, Isidro
Soriano, Virtudes
Guillén, Carlos
Herrera Ceballos, Enrique
Keywords: Melanoma
Càncer de pell
Nodes limfàtics
Skin cancer
Lymph nodes
Issue Date: Sep-2015
Publisher: Elsevier B.V.
Abstract: Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion: Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma.
Note: Versió postprint del document publicat a:
It is part of: European Journal of Cancer, 2015, vol. 51, num. 13, p. 1780-1793
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ISSN: 0959-8049
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Medicina)

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