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Title: | Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma |
Author: | Tejera Vaquerizo, Antonio Nagore, Eduardo Puig i Sardà, Susana Robert, Caroline Saiag, Philippe Martín-Cuevas, Paula Gallego, Elena Herrera Acosta, Enrique Aguilera, José Malvehy, J. (Josep) Carrera Álvarez, Cristina Cavalcanti, Andrea Rull, Ramón Vilalta Solsona, Antonio Lannoy, Emilie Boutros, Celine Benannoune, Naima Tomasic, Gorana Aegerte, Philippe Vidal i Sicart, Sergi Palou, Josep Alós i Hernández, Llúcia Requena, Celia Traves, Víctor Pla, Ángel Bolumar, Isidro Soriano, Virtudes Guillén, Carlos Herrera Ceballos, Enrique |
Keywords: | Melanoma Càncer de pell Nodes limfàtics Melanoma Skin cancer Lymph nodes |
Issue Date: | Sep-2015 |
Publisher: | Elsevier B.V. |
Abstract: | Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion: Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejca.2015.05.023 |
It is part of: | European Journal of Cancer, 2015, vol. 51, num. 13, p. 1780-1793 |
URI: | http://hdl.handle.net/2445/130565 |
Related resource: | https://doi.org/10.1016/j.ejca.2015.05.023 |
ISSN: | 0959-8049 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Medicina) |
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