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http://hdl.handle.net/2445/132010
Title: | Prognostic value of IL-6 in the localized prostatic cancer |
Author: | Alcover García, Juan Filella Pla, Xavier Luque Gálvez, Ma. Pilar Molina, Rafael (Molina Porto) Izquierdo Reyes, Laura Augé Fradera, Josep Maria Alcaraz Asensio, Antonio |
Keywords: | Càncer de pròstata Tumors Marcadors tumorals Prostate cancer Tumors Tumor markers |
Issue Date: | Oct-2010 |
Publisher: | International Institute of Anticancer Research |
Abstract: | AIM: The usefulness of interleukin 6 (IL-6) and its soluble receptor IL-6sR in the prediction of the biochemical recurrence was evaluated in patients with prostate cancer treated with radical prostatectomy. PATIENTS AND METHODS: IL-6 and sIL-6R serum levels were measured in 96 patients with prostate cancer. RESULTS: Using the log-rank test, it was evident that patients with preoperative serum levels of IL-6 higher than 1.2 pg/ml had a significantly increased probability of biochemical recurrence (p=0.031). We also observed that the Gleason score was associated with the risk of progression (p=0.033), but no relation was observed with TNM classification, PSA, % free PSA or sIL-6R. In a multivariate analysis, only IL-6 serum levels remained as a predictor of biochemical recurrence (p=0.040). CONCLUSION: The results presented here demonstrated the usefulness of IL-6 in predicting the biochemical progression of prostate cancer, pointing towards an association between inflammation and the aggressiveness of the tumor. |
Note: | Reproducció del document publicat a: http://ar.iiarjournals.org/content/30/10/4369.long |
It is part of: | Anticancer Research, 2010, vol. 30, num. 10, p. 4369-4372 |
URI: | http://hdl.handle.net/2445/132010 |
ISSN: | 0250-7005 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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