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Title: Cooperative force generation of KIF1A Brownian motors
Author: Oriola Santandreu, David
Casademunt i Viader, Jaume
Keywords: Proteïnes quinases
Protein kinases
Issue Date: 26-Jul-2013
Publisher: American Physical Society
Abstract: KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.
Note: Reproducció del document publicat a:
It is part of: Physical Review Letters, 2013, vol. 111, num. 4, p. 048103
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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