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Title: Is the ORBIT bleeding risk score superior to the HAS-BLED score in anticoagulated atrial fibrillation patients?
Author: Esteve-Pastor, María Asunción
García-Fernández, Amaya
Macías, Manuel
Sogorb, Francisco
Valdés, Mariano
Roldán, Vanesa
Muñiz, Javier
Badimón, Lina, 1953-
Roldán, Inmaculada
Bertomeu Martínez, Vicente
Cequier Fillat, Àngel R.
Lip, Gregory Y.H.
Anguita, Manuel
Marín, Francisco
Keywords: Fibril·lació auricular
Efectes secundaris dels medicaments
Atrial fibrillation
Drug side effects
Issue Date: 23-Sep-2016
Publisher: Japanese Circulation Society
Abstract: Background: several bleeding risk scores have been validated in patients with atrial fibrillation (AF). The ORBIT score has been recently proposed as a simple score with the best ability to predict major bleeding. The present study aimed to test the hypothesis that the ORBIT score was superior to the HAS-BLED score for predicting major bleeding and death in "real world" anticoagulated AF patients. Methods and results: we analyzed the predictive performance for bleeding and death of 406 AF patients who underwent 571 electrical cardioversion procedures and 1,276 patients with permanent/persistent AF from the FANTASIIA registry. In the cardioversion population, 21 patients had major bleeding events and 26 patients died. The predictive performance for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.77 (95% CI 0.66-0.88) and 0.82 (95% CI 0.77-0.93), respectively; P=0.080). For the FANTASIIA population, 46 patients had major bleeding events and 50 patients died. The predictive performances for major bleeding of HASBLED and ORBIT were not significantly different (c-statistics 0.63 (95% CI 0.56-0.71) and 0.70 (95% CI 0.62-0.77), respectively; P=0.116). For death, the predictive performances of HAS-BLED and ORBIT were not significantly different in both populations. The ORBIT score categorized most patients as "low risk". Conclusions: despite the original claims in its derivation paper, the ORBIT score was not superior to HAS-BLED for predicting major bleeding and death in a "real world" oral anticoagulated AF population. (Circ J 2016; 80:2102 - 2108)
Note: Reproducció del document publicat a:
It is part of: Circulation Journal, 2016, vol. 80, num. 10, p. 2102-2108
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ISSN: 1346-9843
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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