Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/133597
Title: | Is the ORBIT bleeding risk score superior to the HAS-BLED score in anticoagulated atrial fibrillation patients? |
Author: | Esteve-Pastor, María Asunción García-Fernández, Amaya Macías, Manuel Sogorb, Francisco Valdés, Mariano Roldán, Vanesa Muñiz, Javier Badimón, Lina, 1953- Roldán, Inmaculada Bertomeu Martínez, Vicente Cequier Fillat, Àngel R. Lip, Gregory Y.H. Anguita, Manuel Marín, Francisco |
Keywords: | Fibril·lació auricular Paravents Efectes secundaris dels medicaments Hemorràgia Coagulació Atrial fibrillation Screens Drug side effects Hemorrhage Coagulation |
Issue Date: | 23-Sep-2016 |
Publisher: | Japanese Circulation Society |
Abstract: | Background: several bleeding risk scores have been validated in patients with atrial fibrillation (AF). The ORBIT score has been recently proposed as a simple score with the best ability to predict major bleeding. The present study aimed to test the hypothesis that the ORBIT score was superior to the HAS-BLED score for predicting major bleeding and death in "real world" anticoagulated AF patients. Methods and results: we analyzed the predictive performance for bleeding and death of 406 AF patients who underwent 571 electrical cardioversion procedures and 1,276 patients with permanent/persistent AF from the FANTASIIA registry. In the cardioversion population, 21 patients had major bleeding events and 26 patients died. The predictive performance for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.77 (95% CI 0.66-0.88) and 0.82 (95% CI 0.77-0.93), respectively; P=0.080). For the FANTASIIA population, 46 patients had major bleeding events and 50 patients died. The predictive performances for major bleeding of HASBLED and ORBIT were not significantly different (c-statistics 0.63 (95% CI 0.56-0.71) and 0.70 (95% CI 0.62-0.77), respectively; P=0.116). For death, the predictive performances of HAS-BLED and ORBIT were not significantly different in both populations. The ORBIT score categorized most patients as "low risk". Conclusions: despite the original claims in its derivation paper, the ORBIT score was not superior to HAS-BLED for predicting major bleeding and death in a "real world" oral anticoagulated AF population. (Circ J 2016; 80:2102 - 2108) |
Note: | Reproducció del document publicat a: https://doi.org/10.1253/circj.CJ-16-0471 |
It is part of: | Circulation Journal, 2016, vol. 80, num. 10, p. 2102-2108 |
URI: | http://hdl.handle.net/2445/133597 |
Related resource: | https://doi.org/10.1253/circj.CJ-16-0471 |
ISSN: | 1346-9843 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
664704.pdf | 321.58 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.