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http://hdl.handle.net/2445/134467
Title: | Improving Free-Energy Estimates from Unidirectional Work Measurements: Theory and Experiment |
Author: | Palassini, Matteo Ritort Farran, Fèlix |
Keywords: | Física de partícules Experiments Particle physics Experiments |
Issue Date: | 2-Aug-2011 |
Publisher: | American Physical Society |
Abstract: | We derive analytical expressions for the bias of the Jarzynski free-energy estimator from N nonequilibrium work measurements, for a generic work distribution. To achieve this, we map the estimator onto the random energy model in a suitable scaling limit parametrized by ( log N ) / μ , where μ measures the width of the lower tail of the work distribution, and then compute the finite- N corrections to this limit with different approaches for different regimes of ( log N ) / μ . We show that these expressions describe accurately the bias for a wide class of work distributions and exploit them to build an improved free-energy estimator from unidirectional work measurements. We apply the method to optical tweezers unfolding and refolding experiments on DNA hairpins of varying loop size and dissipation, displaying both near-Gaussian and non-Gaussian work distributions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1103/PhysRevLett.107.060601 |
It is part of: | Physical Review Letters, 2011, vol. 107, num. 6, p. 060601 |
URI: | http://hdl.handle.net/2445/134467 |
Related resource: | https://doi.org/10.1103/PhysRevLett.107.060601 |
ISSN: | 0031-9007 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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