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http://hdl.handle.net/2445/138757
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DC Field | Value | Language |
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dc.contributor.author | Salort, José de | - |
dc.contributor.author | Cuenca, Marta | - |
dc.contributor.author | Terhorst, Cox | - |
dc.contributor.author | Engel Rocamora, Pablo | - |
dc.contributor.author | Romero Ros, Xavier | - |
dc.date.accessioned | 2019-08-28T07:48:34Z | - |
dc.date.available | 2019-08-28T07:48:34Z | - |
dc.date.issued | 2013-07-31 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/138757 | - |
dc.description.abstract | The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9 (-/-) mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4(+) T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2013.00225 | - |
dc.relation.ispartof | Frontiers in Immunology, 2013, vol. 4, num. 225 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2013.00225 | - |
dc.rights | cc-by (c) Salort, Jose de et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Lupus eritematós | - |
dc.subject.classification | Autoanticossos | - |
dc.subject.classification | Antígens | - |
dc.subject.other | Lupus erythematosus | - |
dc.subject.other | Autoantibodies | - |
dc.subject.other | Antigens | - |
dc.title | Ly9 (CD229) cell surface receptor is crucial for the development of spontaneous autoantibody production to nuclear antigens | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 647380 | - |
dc.date.updated | 2019-08-28T07:48:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23914190 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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647380.pdf | 1.74 MB | Adobe PDF | View/Open |
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