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http://hdl.handle.net/2445/138757
Title: | Ly9 (CD229) cell surface receptor is crucial for the development of spontaneous autoantibody production to nuclear antigens |
Author: | Salort, José de Cuenca, Marta Terhorst, Cox Engel Rocamora, Pablo Romero Ros, Xavier |
Keywords: | Lupus eritematós Autoanticossos Antígens Lupus erythematosus Autoantibodies Antigens |
Issue Date: | 31-Jul-2013 |
Publisher: | Frontiers Media |
Abstract: | The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9 (-/-) mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4(+) T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2013.00225 |
It is part of: | Frontiers in Immunology, 2013, vol. 4, num. 225 |
URI: | http://hdl.handle.net/2445/138757 |
Related resource: | https://doi.org/10.3389/fimmu.2013.00225 |
ISSN: | 1664-3224 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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