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Title: The plasma membrane as a mechanochemical transducer
Author: Roux, Anabel-Lise Le
Quiroga, Xarxa
Walani, Nikhil
Arroyo, Marino
Roca-Cusachs Soulere, Pere
Keywords: Membranes cel·lulars
Cell membranes
Issue Date: 1-Jul-2019
Publisher: The Royal Society Publishing
Abstract: Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical stimuli, and subsequent biochemical responses. Here, we review the role of the PM as a mechanosensing structure. We first analyse how the PM responds to mechanical stresses, and then discuss how this mechanical response triggers downstream biochemical responses. The molecular players involved in PM mechanochemical transduction include sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement. These sensors trigger signalling cascades fundamental both in healthy scenarios and in diseases such as cancer, which cells harness to maintain integrity, keep or restore homeostasis and adapt to their external environment.
It is part of: Philosophical Transactions of the Royal Society B: Biological Sciences, 2019, vol. 374, num. 1779, p. 20180221
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Appears in Collections:Articles publicats en revistes (Biomedicina)
Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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