Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/141217
Title: | BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis |
Author: | Welz, Patrick-Simon Zinna, Valentina M. Symeonidi, Aikaterini Koronowski, Kevin B. Kinouchi, Kenichiro Smith, Jacob G. Marín Guillén, Inés Castellanos, Andrés Furrow, Stephen Aragón, Ferrán Crainiciuc, Georgiana Prats, Neus Martín Caballero, Juan Hidalgo, Andrés Sassone-Corsi, Paolo Aznar Benitah, Salvador |
Keywords: | Ritmes circadiaris Fisiologia Circadian rhythms Physiology |
Issue Date: | 30-May-2019 |
Publisher: | Elsevier |
Abstract: | Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cell.2019.05.009 |
It is part of: | Cell, 2019, vol. 177, num. 6, p. 1436-1447 |
URI: | http://hdl.handle.net/2445/141217 |
Related resource: | http://dx.doi.org/10.1016/j.cell.2019.05.009 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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BMAL1-Driven.pdf | 6.97 MB | Adobe PDF | View/Open |
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