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http://hdl.handle.net/2445/141947
Title: | Fibre-type-specific and Mitochondrial Biomarkers of Muscle Damage after Mountain Races |
Author: | Carmona Dalmases, Gerard Roca, Emma Guerrero, Mario Cussó Fresquet, M. Roser Bárcena, Cristina Mateu Serra, Mercè Cadefau Surroca, Joan Aureli |
Keywords: | Marcadors bioquímics Exercici Fisiologia de l'exercici Cèl·lules musculars Biochemical markers Exercise Exercise physiology Muscle cells |
Issue Date: | 5-Mar-2019 |
Publisher: | Georg Thieme Verlag |
Abstract: | Consequences of running mountain races on muscle damage were investigated by analysing serum muscle enzymes and fibre-type-specific sarcomere proteins. We studied 10 trained amateur and 6 highly trained runners who ran a 35 km and 55 km mountain trail race (MTR), respectively. Levels of creatine kinase (CK), CK-MB isoform (CK-MB), sarcomeric mitochondrial CK (sMtCK), transaminases (AST and ALT), cardiac troponin I (cTnI) and fast (FM) and slow myosin (SM) isoforms, were assessed before, 1 h, 24 h and 48 h after the beginning of MTR. Significant SM increases were found at 24 h in the 55 km group. Levels of CK, CK-MB, AST and cTnI were significantly elevated in both groups following MTR, but in the 55 km group they tended to stabilize in at 48 h. Using pooled data, time-independent serum peaks of SM and CK-MB were significantly correlated. Moreover, concentration of sMtCK was significantly elevated at 1 and 24 h after the race in the 35 km group. Although training volume could confer protection on the mitochondria, the increase in serum CK-MB and SM in the 55 km group might be related to damage to the contractile apparatus type I fibres. Competing in long-distance MTRs might be related to deeper type I muscle fibre damage, even in highly trained individuals. |
Note: | Reproducció del document publicat a: https://doi.org/10.1055/a-0808-4692 |
It is part of: | International Journal of Sports Medicine, 2019, vol. 40, num. 4, p. 253-262 |
URI: | http://hdl.handle.net/2445/141947 |
Related resource: | https://doi.org/10.1055/a-0808-4692 |
ISSN: | 0172-4622 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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691898.pdf | 3.06 MB | Adobe PDF | View/Open |
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