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http://hdl.handle.net/2445/147235
Title: | Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes |
Author: | Cabré, Gisela Garrido Charles, Aida González Lafont, Àngels Moormann, Widukind Langbehn, Daniel Egea, David Lluch, José M. Herges, Rainer Alibés, Ramon Busqué, Félix Gorostiza Langa, Pablo Ignacio Hernando, Jordi |
Keywords: | Pèptids Proteïnes Monòmers Peptides Proteins Monomers |
Issue Date: | 9-May-2019 |
Publisher: | American Chemical Society |
Abstract: | Photoswitchable neurotransmitters of ionotropic kainate receptors were synthesized by tethering a glutamate moiety to disubstituted C2-bridged azobenzenes, which were prepared through a novel methodology that allows access to diazocines with higher yields and versatility. Because of the singular properties of these photochromes, photoisomerizable compounds were obtained with larger thermal stability for their inert cis isomer than for their biologically activity trans state. This enabled selective neuronal firing upon irradiation without background activity in the dark. |
Note: | Versió postprint document publicat a: https://doi.org/10.1021/acs.orglett.9b01222 |
It is part of: | Organic Letters, 2019, vol. 21, num. 10, p. 3780-3784 |
URI: | http://hdl.handle.net/2445/147235 |
Related resource: | https://doi.org/10.1021/acs.orglett.9b01222 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
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File | Description | Size | Format | |
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L01_2019_Organic Letters_21_3780_OA.pdf | 609.65 kB | Adobe PDF | View/Open |
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