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Title: Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes
Author: Cabré, Gisela
Garrido Charles, Aida
González Lafont, Àngels
Moormann, Widukind
Langbehn, Daniel
Egea, David
Lluch, José M.
Herges, Rainer
Alibés, Ramon
Busqué, Félix
Gorostiza Langa, Pablo Ignacio
Hernando, Jordi
Keywords: Pèptids
Issue Date: 9-May-2019
Publisher: American Chemical Society
Abstract: Photoswitchable neurotransmitters of ionotropic kainate receptors were synthesized by tethering a glutamate moiety to disubstituted C2-bridged azobenzenes, which were prepared through a novel methodology that allows access to diazocines with higher yields and versatility. Because of the singular properties of these photochromes, photoisomerizable compounds were obtained with larger thermal stability for their inert cis isomer than for their biologically activity trans state. This enabled selective neuronal firing upon irradiation without background activity in the dark.
Note: Versió postprint document publicat a:
It is part of: Organic Letters, 2019, vol. 21, num. 10, p. 3780-3784
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Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Publicacions de projectes de recerca finançats per la UE

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