Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/148017
Title: | The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study |
Author: | Flores, José Carlos Gracia Lavedan, Esther Benavente, Yolanda Amiano, Pilar Romaguera, Dora Costas, Laura Robles, Claudia González Barca, Eva Banda, Esmeralda de la Alonso Sanz, Esther Aymerich Gregorio, Marta Campo Güerri, Elias Dierssen Sotos, Trinidad Marcos Gragera, Rafael Rodriguez Suarez, Marta María Solans, Marta Gimeno Vázquez, Eva Garcia Martin, Paloma Aragonès Sanz, Núria Shivappa, Nitin Hébert, James R. Pollán, Marina Kogevinas, Manolis Sanjosé Llongueras, Silvia de Castaño-Vinyals, Gemma Casabonne, Delphine |
Keywords: | Leucèmia limfocítica crònica Càncer Chronic lymphocytic leukemia Cancer |
Issue Date: | 23-Dec-2019 |
Publisher: | MDPI AG |
Abstract: | Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu12010048 |
It is part of: | Nutrients, 2019, vol. 12, num. 1 |
URI: | http://hdl.handle.net/2445/148017 |
Related resource: | https://doi.org/10.3390/nu12010048 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
nutrients-12-00048-v2.pdf | 720.27 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License