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https://hdl.handle.net/2445/148934
Title: | Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment |
Author: | García-Otero, Laura López, Marta Guitart Mampel, Mariona Morén Núñez, Constanza Goncé Mellgren, Anna Esteve, Carol Salazar, Laura Gómez, Olga Martínez Crespo, Josep M. (Josep Maria) Torres Murillo, Berta César Diaz, Sergio Garrabou Tornos, Glòria Crispi Brillas, Fàtima Gratacós Solsona, Eduard |
Keywords: | Fetus Antiretrovirals VIH (Virus) Fetus Antiretroviral agents HIV (Viruses) |
Issue Date: | 4-Mar-2019 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | BACKGROUND: Mitochondrial toxicity related to maternal combined antiretroviral treatment (cART) may have an impact on the heart of HIV-exposed uninfected (HEU) fetuses. Our objective was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies. METHODS: Prospective cohort including 47 HIV-infected and 47 non HIV-infected pregnancies. Fetal echocardiography was performed at 26-32 weeks of pregnancy. Umbilical cord blood and placental tissue were collected to study mitochondrial DNA content (mtDNA) (ratio 12SrRNA/RNAseP) and mitochondrial function (cytochrome c oxidase, COX, enzymatic activity) normalized by mitochondrial content (citrate synthase, CS). RESULTS: HEU fetuses showed hypertrophic hearts (left myocardial wall thickness: HIV mean 3.21 mm (SD 0.81) vs. non-HIV 2.72 (0.42), p = 0.012), with signs of systolic and diastolic dysfunction (isovolumic relaxation time: HIV 52.2 ms (8.85) vs. non-HIV 42.5 ms (7.30); p<0.001). Cord blood mitochondrial content was significantly increased in HIV-exposed fetuses (CS activity: HIV 82.9 nmol/min.mg of protein (SD 40.5) vs. non-HIV 56.7 nmol/min.mg of protein (28.4); p = 0.007), with no differences in mtDNA content and COX activity. Both myocardial and mitochondrial mass parameters were significantly associated with zidovudine exposure. CONCLUSIONS: HEU fetuses showed signs of increased myocardial and mitochondrial mass associated with maternal zidovudine treatment, suggesting a fetal adaptive response to cART toxicity. |
Note: | Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat] |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0213279 |
It is part of: | PLoS One, 2019, vol. 14, num. 3, p. e0213279 |
URI: | https://hdl.handle.net/2445/148934 |
Related resource: | https://doi.org/10.1371/journal.pone.0213279 http://hdl.handle.net/2445/128304 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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