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Title: Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
Author: García-Otero, Laura
López, Marta
Guitart Mampel, Mariona
Morén Núñez, Constanza
Goncé Mellgren, Anna
Esteve, Carol
Salazar, Laura
Gómez, Olga
Martínez Crespo, Josep M. (Josep Maria)
Torres, Berta
César, Sergi
Garrabou Tornos, Glòria
Crispi Brillas, Fàtima
Gratacós Solsona, Eduard
Keywords: Fetus
VIH (Virus)
Antiretroviral agents
HIV (Viruses)
Issue Date: 4-Mar-2019
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Mitochondrial toxicity related to maternal combined antiretroviral treatment (cART) may have an impact on the heart of HIV-exposed uninfected (HEU) fetuses. Our objective was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies. METHODS: Prospective cohort including 47 HIV-infected and 47 non HIV-infected pregnancies. Fetal echocardiography was performed at 26-32 weeks of pregnancy. Umbilical cord blood and placental tissue were collected to study mitochondrial DNA content (mtDNA) (ratio 12SrRNA/RNAseP) and mitochondrial function (cytochrome c oxidase, COX, enzymatic activity) normalized by mitochondrial content (citrate synthase, CS). RESULTS: HEU fetuses showed hypertrophic hearts (left myocardial wall thickness: HIV mean 3.21 mm (SD 0.81) vs. non-HIV 2.72 (0.42), p = 0.012), with signs of systolic and diastolic dysfunction (isovolumic relaxation time: HIV 52.2 ms (8.85) vs. non-HIV 42.5 ms (7.30); p<0.001). Cord blood mitochondrial content was significantly increased in HIV-exposed fetuses (CS activity: HIV 82.9 nmol/ of protein (SD 40.5) vs. non-HIV 56.7 nmol/ of protein (28.4); p = 0.007), with no differences in mtDNA content and COX activity. Both myocardial and mitochondrial mass parameters were significantly associated with zidovudine exposure. CONCLUSIONS: HEU fetuses showed signs of increased myocardial and mitochondrial mass associated with maternal zidovudine treatment, suggesting a fetal adaptive response to cART toxicity.
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It is part of: PLoS One, 2019, vol. 14, num. 3, p. e0213279
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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