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Title: Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductivetechnologies: a cohort study
Author: Valenzuela Alcaraz, Brenda I.
Serafin, Anna M.
Sepúlveda Martínez, Álvaro
Casals Soler, Gemma
Rodríguez López, Mérida
Garcia Otero, Laura
Cruz Lemini, Mónica Cristina
Bijnens, Bart
Sitges Carreño, Marta
Balasch Cortina, Juan
Gratacós Solsona, Eduard
Crispi Brillas, Fàtima
Keywords: Reproducció assistida
Control de la natalitat
Reproductive technology
Birth control
Issue Date: 13-Jun-2018
Publisher: John Wiley & Sons
Abstract: OBJECTIVE: To assess the postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies (ART) in children at 3 years of age. DESIGN: A cohort study of children conceived by ART. SETTING: Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain. POPULATION SAMPLE: Eighty singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood. METHODS: Cardiovascular evaluation was performed at 3 years of corrected age, including echocardiography, carotid intima-media (cIMT) by ultrasound, and blood pressure. MAIN OUTCOME MEASURES: Postnatal persistence of cardiovascular changes in children conceived by ART. RESULTS: Compared with controls, children conceived by ART showed larger atria (right atrial area: control 4.9 cm2 (0.9) versus ART 5.5 cm2 (0.9), P < 0.001), more globular ventricles (right ventricular sphericity index: control mean 1.8 (SD 0.5) versus ART 1.6 (0.2), P < 0.001), and signs of systolic (tricuspid annular plane systolic excursion: control 18 mm (2) versus ART 16 mm (3), P < 0.001) and diastolic dysfunction (isovolumic relaxation time: control 68 ms (12) versus ART 79 ms (12), P < 0.001). ART children also presented increased systolic blood pressure (control 90 mmHg (6) versus ART 94 mmHg (5), P < 0.003) and cIMT (control 0.52 μm (0.14) versus ART 0.60 μm (0.16), P < 0.001) as compared with those spontaneously conceived. CONCLUSIONS: Cardiovascular changes previously reported in ART fetuses persist postnatally at 3 years of age. These results underscore the importance of future studies for assessing the long-term cardiovascular health associated with ART. TWEETABLE ABSTRACT: Cardiovascular changes described in fetuses conceived by ART, persist in children at 3 years of age.
Note: Versió postprint del document publicat a:
It is part of: BJOG: An International Journal of Obstetrics and Gynaecology, 2018, vol. 126, num. 2, p. 291-298
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ISSN: 1470-0328
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)

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