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http://hdl.handle.net/2445/149342
Title: | Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductivetechnologies: a cohort study |
Author: | Valenzuela Alcaraz, Brenda I. Serafin, Anna M. Sepúlveda Martínez, Álvaro Casals Soler, Gemma Rodríguez López, Mérida Garcia Otero, Laura Cruz Lemini, Mónica Cristina Bijnens, Bart Sitges Carreño, Marta Balasch Cortina, Juan Gratacós Solsona, Eduard Crispi Brillas, Fàtima |
Keywords: | Reproducció assistida Control de la natalitat Reproductive technology Birth control |
Issue Date: | 13-Jun-2018 |
Publisher: | John Wiley & Sons |
Abstract: | OBJECTIVE: To assess the postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies (ART) in children at 3 years of age. DESIGN: A cohort study of children conceived by ART. SETTING: Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain. POPULATION SAMPLE: Eighty singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood. METHODS: Cardiovascular evaluation was performed at 3 years of corrected age, including echocardiography, carotid intima-media (cIMT) by ultrasound, and blood pressure. MAIN OUTCOME MEASURES: Postnatal persistence of cardiovascular changes in children conceived by ART. RESULTS: Compared with controls, children conceived by ART showed larger atria (right atrial area: control 4.9 cm2 (0.9) versus ART 5.5 cm2 (0.9), P < 0.001), more globular ventricles (right ventricular sphericity index: control mean 1.8 (SD 0.5) versus ART 1.6 (0.2), P < 0.001), and signs of systolic (tricuspid annular plane systolic excursion: control 18 mm (2) versus ART 16 mm (3), P < 0.001) and diastolic dysfunction (isovolumic relaxation time: control 68 ms (12) versus ART 79 ms (12), P < 0.001). ART children also presented increased systolic blood pressure (control 90 mmHg (6) versus ART 94 mmHg (5), P < 0.003) and cIMT (control 0.52 μm (0.14) versus ART 0.60 μm (0.16), P < 0.001) as compared with those spontaneously conceived. CONCLUSIONS: Cardiovascular changes previously reported in ART fetuses persist postnatally at 3 years of age. These results underscore the importance of future studies for assessing the long-term cardiovascular health associated with ART. TWEETABLE ABSTRACT: Cardiovascular changes described in fetuses conceived by ART, persist in children at 3 years of age. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1111/1471-0528.15246 |
It is part of: | BJOG: An International Journal of Obstetrics and Gynaecology, 2018, vol. 126, num. 2, p. 291-298 |
URI: | http://hdl.handle.net/2445/149342 |
Related resource: | https://doi.org/10.1111/1471-0528.15246 |
ISSN: | 1470-0328 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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