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Title: Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation
Author: Giralt Torroella, Albert
Brito, Verónica
Pardo Muñoz, Mònica
Rubio Abejón, Sara Esmeralda
Marion Poll, Lucile
Martín Ibáñez, Raquel
Zamora-Moratalla, Alfonsa
Bosch, Carles
Ballesteros, Jesús J.
Blasco, Esther
García-Torralba, Aída
Pascual Sánchez, Marta
Pumarola, Martí
Alberch i Vié, Jordi, 1959-
Ginés Padrós, Silvia
Martín, Eduardo D.
Segovia, José Carlos
Soriano García, Eduardo
Canals i Coll, Josep M.
Keywords: Neurociències
Issue Date: 1-Jan-2020
Publisher: Elsevier
Abstract: Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in developing hippocampal calbindin-positive CA1 pyramidal neurons (CB-CA1-PNs), induces adult alterations affecting spatial memory. In the same mice, CA3-CA1 synaptic plasticity and spine density and morphology in adult CB-CA1-PNs were severely compromised. RNAseq experiments in developing hippocampus identified an aberrant increase on the Visinin-like protein 1 (VSNL1) expression in the hippocampi devoid of Helios. This aberrant increase on VSNL1 levels was localized in the CB-CA1-PNs. Normalization of VSNL1 levels in CB-CA1-PNs devoid of Helios rescued their spine loss in vitro. Our study identifies a novel and specific developmental molecular pathway involved in the maturation and function of a CA1 pyramidal neuronal subtype.
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It is part of: Experimental Neurology, 2020, vol. 323, p. 113095
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ISSN: 0014-4886
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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