Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/153989
Title: | Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation |
Author: | Giralt Torroella, Albert Brito, Verónica Pardo Muñoz, Mònica Rubio Abejón, Sara Esmeralda Marion Poll, Lucile Martín Ibáñez, Raquel Zamora-Moratalla, Alfonsa Bosch, Carles Ballesteros, Jesús J. Blasco, Esther García-Torralba, Aída Pascual Sánchez, Marta Pumarola, Martí Alberch i Vié, Jordi, 1959- Ginés Padrós, Silvia Martín, Eduardo D. Segovia, José Carlos Soriano García, Eduardo Canals i Coll, Josep M. |
Keywords: | Neurociències Neurosciences |
Issue Date: | 1-Jan-2020 |
Publisher: | Elsevier |
Abstract: | Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in developing hippocampal calbindin-positive CA1 pyramidal neurons (CB-CA1-PNs), induces adult alterations affecting spatial memory. In the same mice, CA3-CA1 synaptic plasticity and spine density and morphology in adult CB-CA1-PNs were severely compromised. RNAseq experiments in developing hippocampus identified an aberrant increase on the Visinin-like protein 1 (VSNL1) expression in the hippocampi devoid of Helios. This aberrant increase on VSNL1 levels was localized in the CB-CA1-PNs. Normalization of VSNL1 levels in CB-CA1-PNs devoid of Helios rescued their spine loss in vitro. Our study identifies a novel and specific developmental molecular pathway involved in the maturation and function of a CA1 pyramidal neuronal subtype. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.expneurol.2019.113095 |
It is part of: | Experimental Neurology, 2020, vol. 323, p. 113095 |
URI: | http://hdl.handle.net/2445/153989 |
Related resource: | https://doi.org/10.1016/j.expneurol.2019.113095 |
ISSN: | 0014-4886 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
693890.pdf | 5.87 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License