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https://hdl.handle.net/2445/154867
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DC Field | Value | Language |
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dc.contributor.author | Farinello, Diego | - |
dc.contributor.author | Wozińska, Monika | - |
dc.contributor.author | Lenti, Elisa | - |
dc.contributor.author | Genovese, Luca | - |
dc.contributor.author | Bianchessi, Silvia | - |
dc.contributor.author | Migliori, Edoardo | - |
dc.contributor.author | Sacchetti, Nicolò | - |
dc.contributor.author | di Lillo, Alessia | - |
dc.contributor.author | Bertilaccio, Maria Teresa Sabrina | - |
dc.contributor.author | de Lalla, Claudia | - |
dc.contributor.author | Valsecchi, Roberta | - |
dc.contributor.author | Gleave, Sabrina Bascones | - |
dc.contributor.author | Lligé, David | - |
dc.contributor.author | Scielzo, Cristina | - |
dc.contributor.author | Mauri, Laura | - |
dc.contributor.author | Ciampa, Maria Grazia | - |
dc.contributor.author | Scarfò, Lydia | - |
dc.contributor.author | Bernardi, Rosa | - |
dc.contributor.author | Lazarevic, Dejan | - |
dc.contributor.author | González Farré, Blanca | - |
dc.contributor.author | Bongiovanni, Lucia | - |
dc.contributor.author | Campo Güerri, Elias | - |
dc.contributor.author | Cerutti, Andrea | - |
dc.contributor.author | Ponzoni, Maurilio | - |
dc.contributor.author | Pattini, Linda | - |
dc.contributor.author | Caligaris-Cappio, Federico | - |
dc.contributor.author | Ghia, Paolo | - |
dc.contributor.author | Brendolan, Andrea | - |
dc.date.accessioned | 2020-04-02T17:17:52Z | - |
dc.date.available | 2020-04-02T17:17:52Z | - |
dc.date.issued | 2018-05-03 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/2445/154867 | - |
dc.description.abstract | In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells and molecular pathways involved remain largely unknown. Here, we demonstrate that leukemic B lymphocytes induce the activation of retinoid acid synthesis and signaling in the microenvironment. Inhibition of RA-signaling in stromal cells causes deregulation of genes associated with adhesion, tissue organization and chemokine secretion including the B-cell chemokine CXCL13. Notably, reducing retinoic acid precursors from the diet or inhibiting RA-signaling through retinoid-antagonist therapy prolong survival by preventing dissemination of leukemia cells into lymphoid tissues. Furthermore, mouse and human leukemia cells could be distinguished from normal B-cells by their increased expression of Rarγ2 and RXRα, respectively. These findings establish a role for retinoids in murine CLL pathogenesis, and provide new therapeutic strategies to target the microenvironment and to control disease progression. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-04150-7 | - |
dc.relation.ispartof | Nature Communications, 2018, vol. 9, p. 1787 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-018-04150-7 | - |
dc.rights | cc-by (c) Farinello, D. et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Retinoides | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Citoquines | - |
dc.subject.other | Retinoids | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Cytokines | - |
dc.title | A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 680392 | - |
dc.date.updated | 2020-04-02T17:17:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29725010 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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680392.pdf | 2.91 MB | Adobe PDF | View/Open |
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