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Title: Investigation of the N-terminus amino functional of Arg10-Teixobactin
Author: Abdel Monaim, Shimaa A. H.
Noki, Sikabwe
Ramchuran, Estelle J.
El-Faham, Ayman
Albericio Palomera, Fernando
de la Torre, Beatriz G.
Keywords: Síntesi de pèptids
Mycobacterium tuberculosis
Peptide synthesis
Mycobacterium tuberculosis
Issue Date: 28-Sep-2017
Publisher: MDPI
Abstract: Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity.
Note: Reproducció del document publicat a:
It is part of: Molecules, 2017, vol. 22, num. 10, p. 1632
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ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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