Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/155533
Title: | Bioactive compounds of cooked tomato sauce modulate oxidative stress and arachidonic acid cascade induced by oxidized LDL in macrophage cultures |
Author: | Storniolo, Carolina Emilia Sacanella, Ignasi Mitjavila Cors, Maria Teresa Lamuela Raventós, Rosa Ma. Moreno Aznárez, Juan José |
Keywords: | Cuina (Tomàquets) Aterosclerosi Cooking (Tomatoes) Atherosclerosis |
Issue Date: | 13-Aug-2019 |
Publisher: | MDPI |
Abstract: | Sofrito is a mix of tomato, onion, garlic, and olive oil, which contains phenolic compounds and carotenoids. Consumption of tomato-based sofrito has been related to a lower risk of cardiovascular events, but the mechanisms behind such beneficial effects remain unclear. This study aimed to analyze the effects of representative sofrito compounds such as naringenin, hydroxytyrosol, lycopene, and β-carotene on mechanisms involved in the pathogenesis of atherosclerosis. We demonstrated that both phenolic compounds and both carotenoids studied were able to inhibit low density lipoproteins (LDL) oxidation, as well as oxidative stress and eicosanoid production induced by oxidized LDL (oxLDL) in macrophage cultures. These effects were not the consequences of disturbing oxLDL uptake by macrophages. Finally, we observed an additive effect of these sofrito compounds, as well as the activity of a main naringenin metabolite, naringenin 7-O-β-d-glucuronide on LDL oxidation and oxidative stress. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu11081880 |
It is part of: | Nutrients, 2019, vol. 11, num. 8 |
URI: | http://hdl.handle.net/2445/155533 |
Related resource: | https://doi.org/10.3390/nu11081880 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
691735.pdf | 1.45 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License