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http://hdl.handle.net/2445/157803
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DC Field | Value | Language |
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dc.contributor.author | Low, Dorrain Yanwen | - |
dc.contributor.author | Lefèvre Arbogast, Sophie | - |
dc.contributor.author | González-Domínguez, Raúl | - |
dc.contributor.author | Urpí Sardà, Mireia | - |
dc.contributor.author | Micheau, Pierre | - |
dc.contributor.author | Petera, Melanie | - |
dc.contributor.author | Centeno, Delphine | - |
dc.contributor.author | Durand, Stephanie | - |
dc.contributor.author | Pujos Guillot, Estelle | - |
dc.contributor.author | Korosi, Aniko | - |
dc.contributor.author | Lucassen, Paul J. | - |
dc.contributor.author | Aigner, Ludwig | - |
dc.contributor.author | Proust Lima, Cécile | - |
dc.contributor.author | Hejblum, Boris P. | - |
dc.contributor.author | Helmer, Catherine | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.contributor.author | Thuret, Sandrine | - |
dc.contributor.author | Samieri, Cécilia | - |
dc.contributor.author | Manach, Claudine | - |
dc.date.accessioned | 2020-04-28T09:10:05Z | - |
dc.date.available | 2020-06-20T05:10:23Z | - |
dc.date.issued | 2019-06-20 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/2445/157803 | - |
dc.description.abstract | Scope: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results: A case-control study nested in the prospective Three-City study includes participants aged &65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gen- der, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap-enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium-chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE-ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross-validated Area Under the Receiver Operating Curve = 75% [95% CI 70-80%] compared to 62% [95% CI 56-67%]. Conclusions: The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201900177 | - |
dc.relation.ispartof | Molecular Nutrition & Food Research, 2019, vol. 63, p. 1900177 | - |
dc.relation.uri | https://doi.org/10.1002/mnfr.201900177 | - |
dc.rights | (c) Wiley-VCH, 2019 | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Metabòlits | - |
dc.subject.classification | Dieta | - |
dc.subject.other | Metabolites | - |
dc.subject.other | Diet | - |
dc.title | Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 691806 | - |
dc.date.updated | 2020-04-28T09:10:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31218777 | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
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691806.pdf | 560.96 kB | Adobe PDF | View/Open |
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