Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/157974
Title: | Searching for selective scaffolds against Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase |
Author: | Viayna Gaza, Antonio Vílchez Puyo, David Vázquez, Javier Pérez-Benavente, Susana Bautista, José Manuel Luque Garriga, F. Xavier |
Keywords: | Malària Plasmodium falciparum Malalties parasitàries Fosfats Mutació (Biologia) Malaria Plasmodium falciparum Parasitic diseases Phosphates Mutation (Biology) |
Issue Date: | 7-Aug-2019 |
Publisher: | MDPI |
Abstract: | Malaria is a parasitic disease caused by Plasmodium spp., being one of the major causes of death worldwide with two-hundred million new infections and hundreds of thousands of deaths in 2015. Despite the important advances in its prevention and treatment, its resistance to current drug therapies is still a serious risk in its eradication. There is urgency in finding novel targets and drugs operating by novel mechanisms, avoiding cross-resistance to classical antimalarials. In this context, the bifunctional enzyme Glucose-6- phosphate dehydrogenase 6-phosphogluconolactonase appears to be a promising therapeutic target due to its crucial role in regulating the PPP pathway (pentose phosphate pathway), which is the major source of redox potential in Plasmodium falciparum. In the last few years, our group detected a specific mutation between the human and the Plasmodium falciparum form in the binding site of Glucose-6-phosphate (G6P), the endogenous ligand of Glucose-6-phosphate dehydrogenase (G6PD). This mutation involves the substitution of an Arginine (human) by an Aspartate (parasite), which allowed us to create a validated in-house homology model of PfG6PD. Based on this result, the group has focused their efforts, through different molecular modelling techniques, in the discovery of selective scaffolds against PfG6PD. Current efforts address the development of a complete structural model of the bifunctional enzyme, which may offer novel opportunities to develop molecules capable of inhibiting this relevant enzyme. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/proceedings2019022028 |
It is part of: | MDPI Proceedings, 2019, vol. 22, num. 1, p. 28 |
URI: | https://hdl.handle.net/2445/157974 |
Related resource: | https://doi.org/10.3390/proceedings2019022028 |
ISSN: | 2504-3900 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
691709.pdf | 171.54 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License