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Title: | Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet |
Author: | Hereu, Mercè Ramos Romero, Sara Busquets, Cristina Atienza, Lidia Amézqueta, Susana Miralles Pérez, Bernat Nogués, M. Rosa Méndez, Lucía Medina, Isabel Torres Simón, Josep Lluís |
Keywords: | Microbiota intestinal Diabetis Gastrointestinal microbiome Diabetes |
Issue Date: | 1-Sep-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with d-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with d-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of d-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of d-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-52678-5 |
It is part of: | Scientific Reports, 2019, vol. 9, p. 16628 |
URI: | http://hdl.handle.net/2445/158146 |
Related resource: | https://doi.org/10.1038/s41598-019-52678-5 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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