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http://hdl.handle.net/2445/158153
Title: | Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth |
Author: | Carreras Badosa, Gemma Remesar Betlloch, Xavier Prats Puig, Anna Xargay i Torrent, Sílvia Lizarraga Mollinedo, Esther Zegher, Francis de Ibáñez, Lourdes Bassols, Judit López Bermejo, Abel |
Keywords: | Medicina prenatal Trastorns del metabolisme Rates (Animals de laboratori) Prenatal medicine Disorders of metabolism Rats as laboratory animals |
Issue Date: | 15-May-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Background: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanims underpinning metabolic programming are not. DLK1, a key regulator of fetal development, inhibits adipocyte differentiation and restricts fetal growth. Methods: Assess Dlk1 expression in Wistar rat model of catch-up growth following intrauterine restriction. Dams fed ad libitum deliverd control pups (C) and dams on a 50% calorie-restricted diet delivered pups with low birth weight (R). Restricted offspring fed a standard rat chow showd catch-up growth (R/C) but those kept on a calorie-restricted diet did not (R/R). Results: Decreased Dlk1 expression was observed in adipose tissue and skeletal muscle of R/C pups along with excessive visceral fat accumulation, decreased circulating adiponectin, increased triglycerides and HOMA-IR (from p<0.05 to p<0.001). Moreover, in R/C pups, the reduced Dlk1 expression in adipose tissue and skeletal muscle correlated with visceral fat (r= -0.820; p<0.0001) and HOMA-IR (r= -0.745; p=0.002). Conclusions: Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction. Modulation of Dlk1 expression could be among the targets of the early prevention of fetal preogramming of adult metabolic disorders. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/s41390-019-0428-2 |
It is part of: | Pediatric Research, 2019, vol. 86, p. 195-201 |
URI: | http://hdl.handle.net/2445/158153 |
Related resource: | https://doi.org/10.1038/s41390-019-0428-2 |
ISSN: | 0031-3998 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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