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DC Field | Value | Language |
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dc.contributor.author | Cevey, María | - |
dc.contributor.author | Calvo-Alén, Jaime | - |
dc.contributor.author | Crespo Palomo, Carlos | - |
dc.contributor.author | Robles Marhuenda, Ángel | - |
dc.contributor.author | Smolen, Lee | - |
dc.contributor.author | Cortés-Hernández, Josefina | - |
dc.date.accessioned | 2020-05-04T10:19:12Z | - |
dc.date.available | 2020-05-04T10:19:12Z | - |
dc.date.issued | 2019-12-05 | - |
dc.identifier.issn | 1178-6981 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158560 | - |
dc.description.abstract | Objective: To evaluate the budget impact and the direct costs of the introduction of subcutaneous belimumab (SC) into the Spanish National Health Service (NHS) for patients with systemic lupus erythematosus (SLE) in Spain. Methods: This study was conducted from the Spanish NHS perspective with a time horizon of 3 years. The budget impact analysis compared the cost difference between two scenarios: current market (standard therapy (ST) and intravenous belimumab (IV)) and other market in which patients switched from belimumab IV to belimumab SC until reaching 17% of the total market share. The eligible population was calculated to receive treatment with belimumab, applying the EPISER (study of the prevalence of rheumatic diseases in adult population in Spain) prevalence (91 per 100,000 inhabitants), Autoimmune Systemic Diseases Study Group (GEAS) incidence (2 per 100,000 inhabitants), and the risk of annual mortality to the Spanish adult population. Patients with severe active lupus nephritis and with severe active CNS lupus were excluded. Patients' characteristics, flare rates and severity, and healthcare resource consumption were evaluated based on data from the literature and interviews with an expert panel. A sensitivity analysis was performed. Results: Currently, there is an estimated 34,697 adult patients with SLE in Spain and 3849 patients who are eligible to be treated with belimumab. The introduction of belimumab SC into the Spanish NHS could generate savings in direct healthcare costs of 6 million euros over the 3 years. Conclusion: The introduction of belimumab SC shows direct savings for the Spanish NHS. These savings could contribute to sustainability and decision-making. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Dove Medical Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2147/CEOR.S218464 | - |
dc.relation.ispartof | Clinicoeconomics and Outcomes Research, 2019, vol. 11, p. 757-765 | - |
dc.relation.uri | https://doi.org/10.2147/CEOR.S218464 | - |
dc.rights | cc-by-nc (c) Cevey, María et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Anticossos monoclonals | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Monoclonal antibodies | - |
dc.title | Budget impact analysis of Subcutaneous Belimumab in patients with systemic Lupus Erythematosus in Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 697599 | - |
dc.date.updated | 2020-05-04T10:19:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31824182 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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697599.pdf | 581.04 kB | Adobe PDF | View/Open |
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