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Title: | Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex |
Author: | Tresserra i Rimbau, Anna Castro Barquero, Sara Vitelli Storelli, Facundo Becerra Tomás, Nerea Vázquez Ruiz, Zenaida Díaz López, Andrés Corella Piquer, Dolores Castañer, Olga Romaguera, Dora Vioque, Jesús Alonso Gómez, Ángel M. Wärnberg, Julia Martínez, J. Alfredo, 1957- Serra Majem, Lluís Estruch Riba, Ramon Tinahones, Francisco J. Lapetra, José Pintó Sala, Xavier Tur, Josep Antoni López Miranda, José García Molina, Laura Delgado Rodríguez, Miguel Matía Martín, Pilar Daimiel, Lidia Rubín García, María Vidal, Josep Galdon, Alba Ros Rahola, Emilio Basterra Gortari, Francisco Javier Babio, Nancy Sorlí, José V. Hernáez Camba, Álvaro Konieczna, Jadwiga Notario Barandiaran, Leyre Tojal Sierra, Lucas Pérez López, Jessica Abete, Itziar Álvarez Pérez, Jacqueline Fernández García, José Carlos Santos Lozano, Jose Manuel Galera Cusí, Ana Julibert, Alicia Ruiz Canela, Miguel Martinez Lacruz, Raul Pérez Vega, Karla Alejandra Galmes Panades, Aina María Pastor Polo, Concepción Moreno Rodriguez, Anai Gea, Alfredo Fitó Colomer, Montserrat Lamuela Raventós, Rosa Ma. Salas Salvadó, Jordi |
Keywords: | Obesitat Dieta Flavonoides Diabetis Obesity Diet Flavonoids Diabetes |
Issue Date: | 8-Nov-2019 |
Publisher: | MDPI |
Abstract: | Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/antiox8110537 |
It is part of: | Antioxidants, 2019, vol. 11, num. 8, p. 537 |
URI: | https://hdl.handle.net/2445/158848 |
Related resource: | https://doi.org/10.3390/antiox8110537 |
ISSN: | 2076-3921 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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