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dc.contributor.authorLavi, Ido-
dc.contributor.authorMeunier, Nicolas-
dc.contributor.authorVoituriez, Raphaël-
dc.contributor.authorCasademunt i Viader, Jaume-
dc.description.abstractWe introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biologicalcell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an activecytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous droplet in the Darcyflow regime, contains a diffusive solute that actively transduces the applied cytoskeleton force. While fairlysimple and analytically tractable, this quasi-two-dimensional model predicts a range of compelling dynamicbehaviours. A linear stability analysis of the system reveals that solute activity first destabilizes a globalpolarization-translation mode, prompting cell motility through spontaneous symmetry breaking. At higheractivity, the system crosses a series of Hopf bifurcations leading to coupled oscillations of droplet shape andsolute concentration profiles. At the nonlinear level, we find traveling-wave solutions associated with uniquepolarized shapes that resemble experimental observations. Altogether, this model offers an analytical paradigmof active deformable systems in which viscous hydrodynamics are coupled to diffusive force transducers.-
dc.format.extent20 p.-
dc.publisherAmerican Physical Society-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofPhysical Review E, 2020, vol. 101, num. 2, p. 022404-
dc.rights(c) American Physical Society, 2020-
dc.sourceArticles publicats en revistes (Física de la Matèria Condensada)-
dc.subject.classificationDinàmica molecular-
dc.subject.classificationDinàmica de fluids-
dc.subject.otherMolecular dynamics-
dc.subject.otherFluid dynamics-
dc.titleMotility and morphodynamics of confined cells-
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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