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https://hdl.handle.net/2445/160887| Title: | Derisking Development by a Cocrystallization Screen of a Novel Selective Inhaled JAK-STAT inhibitor |
| Author: | Llinàs, Antonio Barbas Cañero, Rafael Font Bardia, Ma. Mercedes Smailagic, A. Prohens López, Rafael |
| Keywords: | Cristal·lografia Sals Crystallography Salts |
| Issue Date: | Oct-2019 |
| Publisher: | American Chemical Society |
| Abstract: | The discovery and detailed characterization of several new solid forms of a novel selective inhaled JAK-STAT inhibitor are described. Using a holistic cocrystallization screen approach to explore its formulation landscape, we decrease the risk of future potential development failures due to a nonoptimal pharmacokinetic lung profile or undesired lung effects in humans. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.cgd.8b01492 |
| It is part of: | Crystal Growth & Design, 2019, vol. 19, num. 1, p. 403-414 |
| URI: | https://hdl.handle.net/2445/160887 |
| Related resource: | https://doi.org/10.1021/acs.cgd.8b01492 |
| ISSN: | 1528-7483 |
| Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 691779.pdf | 1.8 MB | Adobe PDF | View/Open |
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