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http://hdl.handle.net/2445/161619
Title: | Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up |
Author: | García Díaz, Anna I. Segura i Fàbregas, Bàrbara Baggio, Hugo César Uribe, Carme Campabadal, Anna Abós, Alexandra Martí Domènech, Ma. Josep Valldeoriola Serra, Francesc Compta, Yaroslau Bargalló Alabart, Núria Junqué i Plaja, Carme, 1955- |
Keywords: | Imatges per ressonància magnètica Malaltia de Parkinson Escorça cerebral Neuropsicologia Magnetic resonance imaging Parkinson's disease Cerebral cortex Neuropsychology |
Issue Date: | 7-Nov-2017 |
Publisher: | Elsevier B.V. |
Abstract: | Background. Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. Methods. Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years. Tests used to assess VS/VP functions included were: Benton's Judgement of Line Orientation (JLOT), Facial Recognition (FRT), and Visual Form Discrimination (VFDT) Tests; Symbol Digit Modalities Test (SDMT); and the Pentagon Copying Test (PCT). Structural magnetic resonance imaging data and FreeSurfer were used to evaluate cortical thinning evolution. Results. PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) differed significantly in the progression of cortical thinning in posterior regions. In PD-MCI patients, the change in VS/VP functions assessed by PCT, JLOT, FRT, and SMDT correlated with the symmetrized percent change of cortical thinning of occipital, parietal, and temporal regions. In PD-NC patients, we also observed a correlation between changes in FRT and thinning in parieto-occipital regions. Conclusion. In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.parkreldis.2017.11.003 |
It is part of: | Parkinsonism & Related Disorders, 2018, vol. 46, p. 62-68 |
URI: | http://hdl.handle.net/2445/161619 |
Related resource: | https://doi.org/10.1016/j.parkreldis.2017.11.003 |
ISSN: | 1353-8020 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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