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dc.contributor.authorGarcía Díaz, Anna I.-
dc.contributor.authorSegura i Fàbregas, Bàrbara-
dc.contributor.authorBaggio, Hugo César-
dc.contributor.authorUribe, Carme-
dc.contributor.authorCampabadal, Anna-
dc.contributor.authorAbós, Alexandra-
dc.contributor.authorMartí Domènech, Ma. Josep-
dc.contributor.authorValldeoriola Serra, Francesc-
dc.contributor.authorCompta, Yaroslau-
dc.contributor.authorBargalló Alabart, Núria​-
dc.contributor.authorJunqué i Plaja, Carme, 1955--
dc.description.abstractBackground. Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. Methods. Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years. Tests used to assess VS/VP functions included were: Benton's Judgement of Line Orientation (JLOT), Facial Recognition (FRT), and Visual Form Discrimination (VFDT) Tests; Symbol Digit Modalities Test (SDMT); and the Pentagon Copying Test (PCT). Structural magnetic resonance imaging data and FreeSurfer were used to evaluate cortical thinning evolution. Results. PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) differed significantly in the progression of cortical thinning in posterior regions. In PD-MCI patients, the change in VS/VP functions assessed by PCT, JLOT, FRT, and SMDT correlated with the symmetrized percent change of cortical thinning of occipital, parietal, and temporal regions. In PD-NC patients, we also observed a correlation between changes in FRT and thinning in parieto-occipital regions. Conclusion. In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions.-
dc.format.extent32 p.-
dc.publisherElsevier B.V.-
dc.relation.isformatofVersió postprint del document publicat a:
dc.relation.ispartofParkinsonism & Related Disorders, 2018, vol. 46, p. 62-68-
dc.rightscc-by-nc-nd (c) Elsevier B.V., 2018-
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationImatges per ressonància magnètica-
dc.subject.classificationMalaltia de Parkinson-
dc.subject.classificationEscorça cerebral-
dc.subject.otherMagnetic resonance imaging-
dc.subject.otherParkinson's disease-
dc.subject.otherCerebral cortex-
dc.titleCortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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