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http://hdl.handle.net/2445/161619
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DC Field | Value | Language |
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dc.contributor.author | García Díaz, Anna I. | - |
dc.contributor.author | Segura i Fàbregas, Bàrbara | - |
dc.contributor.author | Baggio, Hugo César | - |
dc.contributor.author | Uribe, Carme | - |
dc.contributor.author | Campabadal, Anna | - |
dc.contributor.author | Abós, Alexandra | - |
dc.contributor.author | Martí Domènech, Ma. Josep | - |
dc.contributor.author | Valldeoriola Serra, Francesc | - |
dc.contributor.author | Compta, Yaroslau | - |
dc.contributor.author | Bargalló Alabart, Núria | - |
dc.contributor.author | Junqué i Plaja, Carme, 1955- | - |
dc.date.accessioned | 2020-05-20T13:05:56Z | - |
dc.date.available | 2020-05-20T13:05:56Z | - |
dc.date.issued | 2017-11-07 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | http://hdl.handle.net/2445/161619 | - |
dc.description.abstract | Background. Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. Methods. Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years. Tests used to assess VS/VP functions included were: Benton's Judgement of Line Orientation (JLOT), Facial Recognition (FRT), and Visual Form Discrimination (VFDT) Tests; Symbol Digit Modalities Test (SDMT); and the Pentagon Copying Test (PCT). Structural magnetic resonance imaging data and FreeSurfer were used to evaluate cortical thinning evolution. Results. PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) differed significantly in the progression of cortical thinning in posterior regions. In PD-MCI patients, the change in VS/VP functions assessed by PCT, JLOT, FRT, and SMDT correlated with the symmetrized percent change of cortical thinning of occipital, parietal, and temporal regions. In PD-NC patients, we also observed a correlation between changes in FRT and thinning in parieto-occipital regions. Conclusion. In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions. | - |
dc.format.extent | 32 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.parkreldis.2017.11.003 | - |
dc.relation.ispartof | Parkinsonism & Related Disorders, 2018, vol. 46, p. 62-68 | - |
dc.relation.uri | https://doi.org/10.1016/j.parkreldis.2017.11.003 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.classification | Escorça cerebral | - |
dc.subject.classification | Neuropsicologia | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Parkinson's disease | - |
dc.subject.other | Cerebral cortex | - |
dc.subject.other | Neuropsychology | - |
dc.title | Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 674435 | - |
dc.date.updated | 2020-05-20T13:05:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29132765 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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674435.pdf | 1.05 MB | Adobe PDF | View/Open |
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