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Title: Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up
Author: García Díaz, Anna I.
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Uribe, Carme
Campabadal, Anna
Abós, Alexandra
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Bargalló Alabart, Núria​
Junqué i Plaja, Carme, 1955-
Keywords: Imatges per ressonància magnètica
Malaltia de Parkinson
Escorça cerebral
Magnetic resonance imaging
Parkinson's disease
Cerebral cortex
Issue Date: 7-Nov-2017
Publisher: Elsevier B.V.
Abstract: Background. Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. Methods. Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years. Tests used to assess VS/VP functions included were: Benton's Judgement of Line Orientation (JLOT), Facial Recognition (FRT), and Visual Form Discrimination (VFDT) Tests; Symbol Digit Modalities Test (SDMT); and the Pentagon Copying Test (PCT). Structural magnetic resonance imaging data and FreeSurfer were used to evaluate cortical thinning evolution. Results. PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) differed significantly in the progression of cortical thinning in posterior regions. In PD-MCI patients, the change in VS/VP functions assessed by PCT, JLOT, FRT, and SMDT correlated with the symmetrized percent change of cortical thinning of occipital, parietal, and temporal regions. In PD-NC patients, we also observed a correlation between changes in FRT and thinning in parieto-occipital regions. Conclusion. In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions.
Note: Versió postprint del document publicat a:
It is part of: Parkinsonism & Related Disorders, 2018, vol. 46, p. 62-68
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ISSN: 1353-8020
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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