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2017-11-07

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cc-by-nc-nd (c) Elsevier B.V., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/161619

Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up

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https://doi.org/10.1016/j.parkreldis.2017.11.003

Resum

Background. Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. Methods. Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years. Tests used to assess VS/VP functions included were: Benton's Judgement of Line Orientation (JLOT), Facial Recognition (FRT), and Visual Form Discrimination (VFDT) Tests; Symbol Digit Modalities Test (SDMT); and the Pentagon Copying Test (PCT). Structural magnetic resonance imaging data and FreeSurfer were used to evaluate cortical thinning evolution. Results. PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) differed significantly in the progression of cortical thinning in posterior regions. In PD-MCI patients, the change in VS/VP functions assessed by PCT, JLOT, FRT, and SMDT correlated with the symmetrized percent change of cortical thinning of occipital, parietal, and temporal regions. In PD-NC patients, we also observed a correlation between changes in FRT and thinning in parieto-occipital regions. Conclusion. In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions.

Matèries

Imatges per ressonància magnètica, Malaltia de Parkinson, Escorça cerebral, Neuropsicologia

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Magnetic resonance imaging, Parkinson's disease, Cerebral cortex, Neuropsychology

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

GARCÍA DÍAZ, Anna i., SEGURA I FÀBREGAS, Bàrbara, BAGGIO, Hugo césar, URIBE, Carme, CAMPABADAL DELGADO, Anna, ABÓS, Alexandra, MARTÍ DOMÈNECH, Ma. josep, VALLDEORIOLA SERRA, Francesc, COMPTA, Yaroslau, BARGALLÓ ALABART, Núria​, JUNQUÉ I PLAJA, Carme. Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up. _Parkinsonism & Related Disorders_. 2018. Vol. 46, núm. 62-68. [consulta: 21 de gener de 2026]. ISSN: 1353-8020. [Disponible a: https://hdl.handle.net/2445/161619]

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