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http://hdl.handle.net/2445/161986
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DC Field | Value | Language |
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dc.contributor.author | Fernández-Pumarega, Alejandro | - |
dc.contributor.author | Amézqueta, Susana | - |
dc.contributor.author | Fuguet i Jordà, Elisabet | - |
dc.contributor.author | Rosés Pascual, Martí | - |
dc.date.accessioned | 2020-05-22T09:02:53Z | - |
dc.date.available | 2020-05-22T09:02:53Z | - |
dc.date.issued | 2018-03-25 | - |
dc.identifier.issn | 1848-7718 | - |
dc.identifier.uri | http://hdl.handle.net/2445/161986 | - |
dc.description.abstract | Previous studies have shown that a microemulsion electrokinetic chromatography (MEEKC) system can estimate the logarithm of the octanol-water partition coefficient (log Po/w) of neutral solutes. In the present work, the applicability of the method to partially and fully ionized acids has been evaluated. Naproxen, a monoprotic acid, has been used as test solute. The retention factor (k) of this compound has been measured in MEEKC at several values of pH and the retention factor-pH profile has been established. As log Po/w correlates with log kMEEKC for neutral compounds, this correlation has been used to estimate the logarithm of the octanol-water partition coefficient of the neutral (log Po/w(HA)), and the fully ionized (log P o/w(A-)) forms of naproxen. Then, the logarithm of the octanol-water distribution coefficient (log Do/w) of the partially ionized form of the acid has been estimated. The comparison of the estimated values with the ones obtained experimentally using the classical procedures, such as the shake-flask method, shows differences under 0.4 log Do/w units either if the acid is partially ionized or in its neutral form in the most part of the pH range. However, the method overestimates the log Do/w of the highly (>99.5 %) or fully ionized form of naproxen | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IAPC Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.5599/admet.6.1.510 | - |
dc.relation.ispartof | ADMET & DMPK, 2018, vol. 6, num. 1, p. 55-60 | - |
dc.relation.uri | https://doi.org/10.5599/admet.6.1.510 | - |
dc.rights | cc-by (c) Fernández-Pumarega, Alejandro et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Electroforesi capil·lar | - |
dc.subject.classification | Lipofília | - |
dc.subject.other | Capillary electrophoresis | - |
dc.subject.other | Lipophilicity | - |
dc.title | Feasibility of the estimation of octanol-water distribution coefficients of acidic drugs by microemulsion electrokinetic chromatography | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 683718 | - |
dc.date.updated | 2020-05-22T09:02:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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683718.pdf | 545.82 kB | Adobe PDF | View/Open |
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