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Title: | Feasibility of the estimation of octanol-water distribution coefficients of acidic drugs by microemulsion electrokinetic chromatography |
Author: | Fernández-Pumarega, Alejandro Amézqueta, Susana Fuguet i Jordà, Elisabet Rosés Pascual, Martí |
Keywords: | Electroforesi capil·lar Lipofília Capillary electrophoresis Lipophilicity |
Issue Date: | 25-Mar-2018 |
Publisher: | IAPC Publishing |
Abstract: | Previous studies have shown that a microemulsion electrokinetic chromatography (MEEKC) system can estimate the logarithm of the octanol-water partition coefficient (log Po/w) of neutral solutes. In the present work, the applicability of the method to partially and fully ionized acids has been evaluated. Naproxen, a monoprotic acid, has been used as test solute. The retention factor (k) of this compound has been measured in MEEKC at several values of pH and the retention factor-pH profile has been established. As log Po/w correlates with log kMEEKC for neutral compounds, this correlation has been used to estimate the logarithm of the octanol-water partition coefficient of the neutral (log Po/w(HA)), and the fully ionized (log P o/w(A-)) forms of naproxen. Then, the logarithm of the octanol-water distribution coefficient (log Do/w) of the partially ionized form of the acid has been estimated. The comparison of the estimated values with the ones obtained experimentally using the classical procedures, such as the shake-flask method, shows differences under 0.4 log Do/w units either if the acid is partially ionized or in its neutral form in the most part of the pH range. However, the method overestimates the log Do/w of the highly (>99.5 %) or fully ionized form of naproxen |
Note: | Reproducció del document publicat a: https://doi.org/10.5599/admet.6.1.510 |
It is part of: | ADMET & DMPK, 2018, vol. 6, num. 1, p. 55-60 |
URI: | http://hdl.handle.net/2445/161986 |
Related resource: | https://doi.org/10.5599/admet.6.1.510 |
ISSN: | 1848-7718 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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