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dc.contributor.authorSousa Coelho, Ana Luisa de-
dc.contributor.authorRelat Pardo, Joana-
dc.contributor.authorHondares, E.-
dc.contributor.authorPérez Martí, Albert-
dc.contributor.authorRibas Aulinas, Francesc-
dc.contributor.authorVillarroya i Gombau, Francesc-
dc.contributor.authorMarrero González, Pedro F.-
dc.contributor.authorHaro Bautista, Diego-
dc.description.abstractAbstract Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fi broblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21- defi cient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation. ¿De Sousa-Coelho, A. L., J. Relat, E. Hondares, A. Pérez-Martí, F. Ribas, F. Villarroya, P. F. Marrero, and D. Haro. FGF21 mediates the lipid metabolism response to amino acid starvation.-
dc.format.extent12 p.-
dc.publisherAmerican Society for Biochemistry and Molecular Biology-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofJournal of Lipid Research, 2013, vol. 54, num. 7, p. 1786-1797-
dc.rights(c) American Society for Biochemistry and Molecular Biology, 2013-
dc.sourceArticles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)-
dc.subject.classificationMetabolisme dels lípids-
dc.subject.classificationTeixit adipós-
dc.subject.classificationFactors de creixement-
dc.subject.otherLipid metabolism-
dc.subject.otherAdipose tissues-
dc.subject.otherGrowth factors-
dc.subject.otherAmino acids-
dc.titleFGF21 mediates the lipid metabolism response to amino acid starvation-
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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