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http://hdl.handle.net/2445/162499
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DC Field | Value | Language |
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dc.contributor.author | Gladrow, J. | - |
dc.contributor.author | Ribezzi-Crivellari, M. | - |
dc.contributor.author | Ritort Farran, Fèlix | - |
dc.contributor.author | Keyser, U.F. | - |
dc.date.accessioned | 2020-05-26T16:36:36Z | - |
dc.date.available | 2020-05-26T16:36:36Z | - |
dc.date.issued | 2019-01-04 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162499 | - |
dc.description.abstract | While thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here, we systematically investigate transition-path-time symmetry and report evidence of its breakdown on the molecular- and meso-scale out of equilibrium. In automated Brownian dynamics experiments, we establish first-passage-time symmetries of colloids driven by femtoNewton forces in holographically-created optical landscapes confined within microchannels. Conversely, we show that transitions which couple in a path-dependent manner to fluctuating forces exhibit asymmetry. We reproduce this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topological mechanism of symmetry breakdown. Our results are relevant to measurements that capture a single coordinate in a multidimensional free energy landscape, as encountered in electrophysiology and single-molecule fluorescence experiments. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-07873-9 | - |
dc.relation.ispartof | Nature Communications, 2019, vol. 10, p. 55 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-018-07873-9 | - |
dc.rights | cc-by (c) Gladrow, J. et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Energia | - |
dc.subject.classification | Col·loides | - |
dc.subject.classification | Moviment brownià | - |
dc.subject.classification | ADN | - |
dc.subject.other | Energy | - |
dc.subject.other | Colloids | - |
dc.subject.other | Brownian movements | - |
dc.subject.other | DNA | - |
dc.title | Experimental evidence of symmetry breaking of transition-path times | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 688475 | - |
dc.date.updated | 2020-05-26T16:36:37Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/647144/EU//DesignerPores | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/674979/EU//NANOTRANS | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/749944/EU//MUTAnTS | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30610184 | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) Publicacions de projectes de recerca finançats per la UE |
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688475.pdf | 1.4 MB | Adobe PDF | View/Open |
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