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Title: Diagnostic yield of 18F-FDG PET/CT in suspected diagnosis of vascular graft infection: A prospective cohort study
Author: Bowles, Hans
Ambrosioni, Juan
Mestres, Gaspar
Hernández-Meneses, Marta
Sánchez, Nuria
Llopis Pérez, Jaime
Yugueros Castellnou, Xavier
Almela, M. (Manel)
Moreno Camacho, Ma. Asunción
Riambau, Vicente
Fuster Pelfort, David
Miró Meda, José M.
Keywords: Diagnòstic per la imatge
Estudi de casos
Pròtesis vasculars
Diagnostic imaging
Case studies
Blood vessel prosthesis
Issue Date: Feb-2020
Publisher: Mosby
Abstract: Background. Prosthetic vascular graft infection (PVGI) is a severe complication associated with high morbidity and mortality. Clinical diagnosis is complex, requiring image testing such as CT angiography or leukocyte scintigraphy, which has considerable limitations. The aim of this study was to know the diagnostic yield of PET/CT with 18F-Fluorodeoxyglucose (18F-FDG) in patients with suspected PVGI. Methods. We performed a prospective cohort study including 49 patients with suspected PVGI, median age of 62 ± 14 years. Three uptake patterns were defined following published recommendations: (i) focal, (ii) patched (PVGI criteria), and (iii) diffuse (no PVGI criterion). Results. Sensitivity, specificity, and positive and negative predictive values for 18F-FDG-PET/ CT were 88%, 79%, 67%, and 93%, respectively. 18F-FDG-PET/CT identified 14/16 cases of PVGI showing a focal (n = 10) or patched pattern (n = 4), being true negative in 26/33 cases with either a diffuse pattern (n = 16) or without uptake (n = 10). Five of the seven false-positive cases (71%) showed a patched pattern and all coincided with the application of adhesives for PVG placement. Conclusions. 18F-FDG-PET/CT is a useful technique for the diagnosis of PVGI. A patched pattern on PET/CT in patients in whom adhesives were applied for prosthetic vascular graft placement does not indicate infection. (J Nucl Cardiol 2018) Key Words: Fluorodeoxyglucose (FDG) Æ diagnostic and prognostic application Æ PET/CT imaging
It is part of: Journal of Nuclear Cardiology, 2018, vol. 27, num. 1, p. 294-302
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ISSN: 1071-3581
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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