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Title: Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus
Author: Steyn, Angela
Crowther, Nigel J.
Norris, Shane A.
Rabionet Janssen, Raquel
Estivill, Xavier, 1955-
Ramsay, Michèle
Keywords: Diabetis en l'embaràs
Diabetes in pregnancy
Issue Date: 4-Oct-2019
Publisher: Future Medicine
Abstract: Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia.
Note: Versió postprint del document publicat a:
It is part of: Epigenomics, 2019, vol. 11, num. 12
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ISSN: 1750-1911
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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