Please use this identifier to cite or link to this item:
Title: Dynamic Kinetic Resolution and Desymmetrization Processes: A Straightforward Methodology for the Enantioselective Synthesis of Piperidines
Author: Amat Tusón, Mercedes
Bassas Sapé, Oriol
Llor Brunés, Núria
Cantó Espot, Margalida
Pérez Bosch, Maria
Molins i Grau, Elies
Bosch Cartes, Joan
Keywords: Síntesi orgànica
Organic synthesis
Issue Date: 2006
Publisher: Wiley-VCH
Abstract: A straightforward procedure for the synthesis of enantiopure polysubstituted piperidines is reported. It involves the direct generation of chiral non‐racemic oxazolo[3,2‐a ]piperidone lactams that already incorporate carbon substituents on the heterocyclic ring and the subsequent removal of the chiral auxiliary. The key step is a cyclocondensation reaction of (R )‐phenylglycinol or other amino alcohols with racemic or prochiral δ‐oxo (di)acid derivatives in highly stereoselective processes involving dynamic kinetic resolution and/or desymmetrization of diastereotopic or enantiotopic ester groups.
Note: Versió postprint del document publicat a:
It is part of: Chemistry-A European Journal, 2006, vol. 12, num. 30, p. 7872-7881
Related resource:
ISSN: 0947-6539
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
540137.pdf1.42 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.