Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/162922
Title: | Dynamic Kinetic Resolution and Desymmetrization Processes: A Straightforward Methodology for the Enantioselective Synthesis of Piperidines |
Author: | Amat Tusón, Mercedes Bassas Sapé, Oriol Llor Brunés, Núria Cantó Espot, Margalida Pérez Bosch, Maria Molins i Grau, Elies Bosch Cartes, Joan |
Keywords: | Síntesi orgànica Alcaloides Organic synthesis Alkaloids |
Issue Date: | 2006 |
Publisher: | Wiley-VCH |
Abstract: | A straightforward procedure for the synthesis of enantiopure polysubstituted piperidines is reported. It involves the direct generation of chiral non‐racemic oxazolo[3,2‐a ]piperidone lactams that already incorporate carbon substituents on the heterocyclic ring and the subsequent removal of the chiral auxiliary. The key step is a cyclocondensation reaction of (R )‐phenylglycinol or other amino alcohols with racemic or prochiral δ‐oxo (di)acid derivatives in highly stereoselective processes involving dynamic kinetic resolution and/or desymmetrization of diastereotopic or enantiotopic ester groups. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/chem.200600420 |
It is part of: | Chemistry-A European Journal, 2006, vol. 12, num. 30, p. 7872-7881 |
URI: | https://hdl.handle.net/2445/162922 |
Related resource: | https://doi.org/10.1002/chem.200600420 |
ISSN: | 0947-6539 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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540137.pdf | 1.42 MB | Adobe PDF | View/Open |
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