Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/163039
Title: | Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
Author: | Alemany-Navarro, María Cruz, Raquel Real, Eva Segalàs Cosi, Cinto Bertolín, Sara Rabionet Janssen, Raquel Carracedo Álvarez, Ángel Menchón Magriñá, José Manuel Alonso Ortega, María del Pino |
Keywords: | Obesitat Genètica Obesity Genetics |
Issue Date: | 18-May-2020 |
Publisher: | Nature Publishing Group |
Abstract: | The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specific genetic bases for the different OCD dimensions. In this study, we analyze the genomic markers, genes, gene ontology and biological pathways associated with the presence of aggressive/checking, symmetry/order, contamination/cleaning, hoarding, and sexual/religious symptoms, as assessed via the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) in 399 probands. Logistic regression analyses were performed at the single-nucleotide polymorphism (SNP) level. Gene-based and enrichment analyses were carried out for common (SNPs) and rare variants. No SNP was associated with any dimension at a genome-wide level (p < 5 × 10−8). Gene-based analyses showed one gene to be associated with hoarding (SETD3, p = 1.89 × 10−08); a gene highly expressed in the brain and which plays a role in apoptotic processes and transcriptomic changes, and another gene associated with aggressive symptoms (CPE; p = 4.42 × 10−6), which is involved in neurotrophic functions and the synthesis of peptide hormones and neurotransmitters. Different pathways or biological processes were represented by genes associated with aggressive (zinc ion response and lipid metabolism), order (lipid metabolism), sexual/religious (G protein-mediated processes) and hoarding (metabolic processes and anion transport) symptoms after FDR correction; while no pathway was associated with contamination. Specific genomic bases were found for each dimension assessed, especially in the enrichment analyses. Further research with larger samples and different techniques, such as next-generation sequencing, are needed to better understand the differential genetics of OCD dimensions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41398-020-0804-z |
It is part of: | Translational Psychiatry, 2020, vol. 10, p. 151 |
URI: | http://hdl.handle.net/2445/163039 |
Related resource: | https://doi.org/10.1038/s41398-020-0804-z |
ISSN: | 2158-3188 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
701005.pdf | 961.67 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License