Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/163519
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DC Field | Value | Language |
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dc.contributor.author | Bregestovski, Piotr | - |
dc.contributor.author | Maleeva, Galyna | - |
dc.contributor.author | Gorostiza Langa, Pablo Ignacio | - |
dc.date.accessioned | 2020-06-01T08:34:20Z | - |
dc.date.available | 2020-06-01T08:34:20Z | - |
dc.date.issued | 2017-08-31 | - |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | http://hdl.handle.net/2445/163519 | - |
dc.description.abstract | The control of ligand-gated receptors with light using photochromic compounds has evolved from the first handcrafted examples to accurate, engineered receptors, whose development is supported by rational design, high-resolution protein structures, comparative pharmacology and molecular biology manipulations. Photoswitchable regulators have been designed and characterized for a large number of ligand-gated receptors in the mammalian nervous system, including nicotinic acetylcholine, glutamate and GABA receptors. They provide a well-equipped toolbox to investigate synaptic and neuronal circuits in all-optical experiments. This focused review discusses the design and properties of these photoswitches, their applications and shortcomings and future perspectives in the field. | ca |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | John Wiley & Sons | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1111/bph.14022 | - |
dc.relation.ispartof | British Journal of Pharmacology, 2018, vol. 175, num. 11, p. 1892-1902 | - |
dc.relation.uri | http://dx.doi.org/10.1111/bph.14022 | - |
dc.rights | (c) The British Pharmacological Society, 2017 | - |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.classification | Receptors neurals | - |
dc.subject.other | Molecular biology | - |
dc.subject.other | Neural receptor | - |
dc.title | Light-induced regulation of ligand-gated channel activity | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP_SGA1 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/785907/EU//HBP_SGA2 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28859250 | - |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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L01_2018_British Journal of Pharmacology_175_1892_OA.pdf | 325.71 kB | Adobe PDF | View/Open |
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