Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/163721
Title: | The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids |
Author: | Paulo de Andrade, Jean Giordani, R. B. Torras Claveria, Laura Pigni, Natalia Belén Berkov, Strahil Font Bardia, Ma. Mercedes Calvet Pallàs, Maria Teresa Konrath, E. Bueno, K. Sachett, L. G. Dutilh, J. H. Borges, W. D. Viladomat Meya, Francesc Henriques, A. T. Nair, Jerald J. Zuanazzi, José Ângelo Silveira Bastida Armengol, Jaume |
Keywords: | Alcaloides Radiocristal·lografia Alkaloids X-ray crystallography |
Issue Date: | Feb-2016 |
Publisher: | Springer Science + Business Media |
Abstract: | Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s11101-015-9411-7 |
It is part of: | Phytochemistry Reviews, 2016, vol. 15, num. 1, p. 147-160 |
URI: | http://hdl.handle.net/2445/163721 |
Related resource: | https://doi.org/10.1007/s11101-015-9411-7 |
ISSN: | 1568-7767 |
Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
656974.pdf | 1.13 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.