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Title: Sequential ring-closing metathesis-vinyl halide Heck cyclization reactions: access to the tetracyclic ring system of ervitsine
Author: Bennasar Fèlix, M. Lluïsa
Zulaica Gallego, Ester
Solé Arjó, Daniel
Alonso Serrano, Sandra
Keywords: Metàtesi (Química)
Reaccions químiques
Productes naturals
Síntesi orgànica
Metathesis (Chemistry)
Chemical reactions
Natural products
Organic synthesis
Issue Date: 17-Jun-2012
Publisher: Elsevier B.V.
Abstract: A chemoselective indole-templated ring-closing metathesis is used to assemble the cyclohepta[b]indole substructure of the indole alkaloid ervitsine. A subsequent intramolecular Heck coupling of the resulting alkene functionality with an amino-tethered vinyl halide accomplishes the closure of the unique 2- azabicyclo[4.3.1]decane framework of the alkaloid with concomitant incorporation of the exocyclic Eethylidene substituent.
Note: Versió postprint del document publicat a:
It is part of: Tetrahedron, 2012, vol. 68, num. 24, p. 4641-4648
ISSN: 0040-4020
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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