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https://hdl.handle.net/2445/164274| Title: | Sequential ring-closing metathesis-vinyl halide Heck cyclization reactions: access to the tetracyclic ring system of ervitsine |
| Author: | Bennasar Fèlix, M. Lluïsa Zulaica Gallego, Ester Solé Arjó, Daniel Alonso Serrano, Sandra |
| Keywords: | Metàtesi (Química) Reaccions químiques Productes naturals Síntesi orgànica Alcaloides Metathesis (Chemistry) Chemical reactions Natural products Organic synthesis Alkaloids |
| Issue Date: | 17-Jun-2012 |
| Publisher: | Elsevier B.V. |
| Abstract: | A chemoselective indole-templated ring-closing metathesis is used to assemble the cyclohepta[b]indole substructure of the indole alkaloid ervitsine. A subsequent intramolecular Heck coupling of the resulting alkene functionality with an amino-tethered vinyl halide accomplishes the closure of the unique 2- azabicyclo[4.3.1]decane framework of the alkaloid with concomitant incorporation of the exocyclic Eethylidene substituent. |
| Note: | Versió postprint del document publicat a: |
| It is part of: | Tetrahedron, 2012, vol. 68, num. 24, p. 4641-4648 |
| URI: | https://hdl.handle.net/2445/164274 |
| ISSN: | 0040-4020 |
| Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 622691.pdf | 592.55 kB | Adobe PDF | View/Open |
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