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http://hdl.handle.net/2445/164367
Title: | Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer |
Author: | Puig, Pere Erill, Nadina Terricabras, Marta Subirana, Isaac González-García, Judit Asensi-Puig, Adrià Donovan, Michael J. Mengual Brichs, Lourdes Agulló-Ortuño, M. Teresa Olivan Riera, Mireia Alcaraz Asensio, Antonio López-Martín, José A. Torres, Inés de Rodríguez Peralto, José Luis Rodríguez-Antolín, Alfredo Morote, Juan González-Rumayor, Víctor |
Keywords: | Marcadors bioquímics Càncer de pròstata Proteïnes Biochemical markers Prostate cancer Proteins |
Issue Date: | 30-Jan-2019 |
Publisher: | BioMed Central |
Abstract: | Objectives: To apply a systems pathology-based approach to the quantification of nuclear Active β-catenin and human leukocyte antigen class I, and assess the biomarker involvement in a cohort of prostate tumor patients. Results: The systems pathology approach applied allows a precise quantification of the marker expression in the different cell compartments as well as the determination of the areas that coexpress two markers. Our data shows that the accumulation of β-catenin in the nuclear compartment is significantly decreased in the adjacent normal areas when compared to tumor of the same patients (p < 0.001). In conclusion, the application of this novel multiple immunofluorescence assay demonstrates that the upregulation of Active β-catenin is a relatively common feature of prostate tumor development, and further supports the activation of the Wnt/β-catenin pathway in prostate cancer progression. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13104-019-4100-z |
It is part of: | BMC Research Notes, 2019, vol. 12, p. 68 |
URI: | http://hdl.handle.net/2445/164367 |
Related resource: | https://doi.org/10.1186/s13104-019-4100-z |
ISSN: | 1756-0500 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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