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https://hdl.handle.net/2445/164558| Title: | Optimization of Xanthatin Extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties |
| Author: | Romero, M. Zanuy, M. Rosell, E. Cascante i Serratosa, Marta Piulats, Josep M. Font Bardia, Ma. Mercedes Balzirini, J. de Clercq, E. Pujol Dilmé, M. Dolors |
| Keywords: | Plantes medicinals Medicaments antivírics Radiocristal·lografia Medicinal plants Antiviral agents X-ray crystallography |
| Issue Date: | 27-Jan-2015 |
| Publisher: | Elsevier Masson SAS |
| Abstract: | The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejmech.2014.11.060 |
| It is part of: | European Journal of Medicinal Chemistry, 2015, vol. 90, p. 491-496 |
| URI: | https://hdl.handle.net/2445/164558 |
| Related resource: | https://doi.org/10.1016/j.ejmech.2014.11.060 |
| ISSN: | 0223-5234 |
| Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
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