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http://hdl.handle.net/2445/165079| Title: | Multicomponent Reactions upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents |
| Author: | Pedrola, Marina Jorba, Marta Jardas, Eda Jardi, Ferran Ghashghaei, Ouldouz Viñas, Miquel Lavilla Grífols, Rodolfo |
| Keywords: | Antibiòtics Medicaments Bacteris Isonitrils Antibiotics Drugs Bacteria Isocyanides |
| Issue Date: | 4-Jul-2019 |
| Publisher: | Frontiers Media |
| Abstract: | Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the desired adducts in one-step. The analogs display meaningful structural features of the initial drug together with relevant modifications at several points, keeping antibiotic potency and showing satisfactory antimicrobial profile (good activity levels and reduced growth rates), especially against methicillin-resistant Staphylococcus aureus. The new products may open new possibilities to fight bacterial infections. |
| Note: | Reproducció del document publicat a: https://doi.org/10.3389/fchem.2019.00475 |
| It is part of: | Frontiers in Chemistry, 2019, vol. 7, p. 475 |
| URI: | http://hdl.handle.net/2445/165079 |
| Related resource: | https://doi.org/10.3389/fchem.2019.00475 |
| ISSN: | 2296-2646 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 691038.pdf | 2.52 MB | Adobe PDF | View/Open |
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