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Title: | Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity |
Author: | Muzzio, María L. Kabakian, María L. Morosán-Allo, Yanina Ferrari, Silvia Fallahi, Poupak Fernández, Jorgelina Santucci de Magistris, Maria Andrés Lacueva, Ma. Cristina Antonelli, Alessandro Brenta, Gabriela Meroño, Tomás |
Keywords: | Obesitat en els infants Malalties del ronyó Obesity in children Kidney diseases |
Issue Date: | 24-Mar-2020 |
Publisher: | Elsevier B.V. |
Abstract: | Background and aims Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/OB are unknown. Methods and results Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p < 0.05). Similarly to high sensitivity C-reactive protein (hsCRP), there were no differences in serum chemokines between children with GH or not (all p > 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p < 0.05) and for MIG with z-BMI (r = −0.26; p < 0.05) and with NEFA (r = 0.27; p < 0.05). Conclusion GH was not associated with higher chemokine levels in prepubertal children with OW/OB. Decreased rather than elevated GFR values were correlated with obesity and worse metabolic profiles. Chemokines levels in children with severe OB suggest a regulation of the immune response. Follow-up studies are needed to address the clinical implications of these findings. Keywords ObesityChildrenChemokinesHyperfiltrationRenal disease |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.numecd.2020.03.012 |
It is part of: | Nutrition Metabolism and Cardiovascular Diseases, 2020 |
URI: | http://hdl.handle.net/2445/168548 |
Related resource: | https://doi.org/10.1016/j.numecd.2020.03.012 |
ISSN: | 0939-4753 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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