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Title: Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders
Author: La Dure-Molla, Muriel de
Fournier, Benjamin Philippe
Manzanares Céspedes, María Cristina
Acevedo, Ana Carolina
Hennekam, Raoul C.
Friedlander, Lisa
Boy-Lefèvre, Marie-Laure
Kerner, Stephane
Toupenay, Steve
Garrec, Pascal
Vi-Fane, Brigite
Felizardo, Rufino
Berteretche, Marie Violaine
Jordan, Laurence
Ferré, François
Clauss, François
Jung, Sophie
Chalendar, Myriam de
Troester, Sebastien
Kawczynski, Marzena
Chaloyard, Jessica
International Group of Dental Nomenclature
Manière, Marie Cécile
Berdal, Ariane
Bloch-Zupan, Agnès
Keywords: Malformacions dentals
Malalties rares
Dental abnormalities
Rare diseases
Issue Date: 17-Jul-2019
Publisher: Wiley
Abstract: Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a diagnostic tool by dentists, clinical geneticists, and other health care providers. The definitions are part of the series Elements of Morphology and have been established after careful discussions within an international group of experienced dentists and geneticists. The classification system was elaborated in the French collaborative network 'TÊTECOU' and the affiliated O-Rares reference/competence centers. The classification includes isolated and syndromic disorders with oral and dental anomalies, to which causative genes and main extraoral signs and symptoms are added. A systematic literature analysis yielded 408 entities of which a causal gene has been identified in 79%. We classified dental disorders in eight groups: dental agenesis, supernumerary teeth, dental size and/or shape, enamel, dentin, dental eruption, periodontal and gingival, and tumor-like anomalies. We aim the classification to act as a shared reference for clinical and epidemiological studies. We welcome critical evaluations of the definitions and classification and will regularly update the classification for newly recognized conditions.
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It is part of: American Journal of Medical Genetics Part A, 2019, vol. 179A, num. 10, p. 1913-1981
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ISSN: 1552-4825
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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