Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/171263
Title: Shared heritability and functional enrichment across six solid cancers
Author: Jiang, Xia
Finucane, Hilary K.
Schumacher, Fredrick R.
Schmit, Stephanie L.
Tyrer, Jonathan P.
Han, Younghun
Michailidou, Kyriaki
Lesseur, Corina
Kuchenbaecker, Karoline B.
Dennis, Joe
Conti, David V.
Cunningham, Julie M.
John, Esther M.
Couch, Fergus J.
Bolla, Manjeet K.
Casey, Graham
Margolin, Sara
Goodman, Gary
Evans, D. Gareth
Riggan, Marjorie J.
Gago-Dominguez, Manuela
Jenkins, Mattias
Fostira, Florentia
Kaneva, Radka
Arnold, Susanne M.
Offit, Kenneth
Ruyck, Kim De
Olsson, Håkan
Arun, Banu K.
Schleutker, Johanna
Aronson, Kristan J.
Caligo, Maria A.
Tardón, Adonina
Edlund, Christopher K.
Ingles, Sue Ann
Hsu, Li
Rosenstein, Barry S.
Chenevix-Trench, Georgia
McKay, James D.
Claes, Kathleen B. M.
Chanock, Stephen J.
Nordestgaard, Børge G.
Park, Jong Y.
Kupryjanczyk, Jolanta
Cadoni, Gabriella
Neal, David E.
Diez, Orland
Ferris, Robert L.
Stefansson, Kari
Cannon-Albright, Lisa A.
Weinberg, Clarice R.
McGuffog, Lesley
Raskin, Leon
Mannermaa, Arto
Kibel, Adam S.
Neuhausen, Susan L.
Hulick, Peter J.
Shen, Hongbing
Wichmann, H-Erich
Goldberg, Mark S.
Greene, Mark H.
Maehle, Lovise
Yannoukakos, Drakoulis
Garber, Judy
Webb, Penelope M.
Weissler, Mark C.
Pejovic, Tanja
Bojesen, Stig E.
Toland, Amanda E.
Blomqvist, Carl
Knight, Julia A.
Huntsman, David G.
Dörk, Thilo
Gaudet, Mia M.
Hong, Yun-Chul
Whittemore, Alice S.
Torres, Diana
Hung, Rayjean J.
García-Closas, Montserrat
Li, Li
Friedman, Eitan
Hillemanns, Peter
Haugen, Aage
Cruz Correa, Marcia
Wolk, Alicja
Olopade, Olufunmilayo I.
Risch, Harvey A.
Terry, Kathryn L.
Hamdy, Freddie C.
Burwinkel, Barbara
Brauch, Hiltrud
Parsons, Michael T.
Tangen, Catherine M.
Travis, Ruth C.
Middha, Pooja
Terry, Mary Beth
Newcomb, Lisa F.
Nielsen, Finn C.
Ness, Andrew R.
Stanford, Janet L.
Kraft, Peter
Montagna, Marco
Brenton, James D.
Roobol, Monique J.
Thibodeau, Stephen N.
Sundfeldt, Karin
Hampe, Jochen
Lubiński, Jan
Tung, Nadine
Nevanlinna, Heli
Chang-Claude, Jenny
Stone, Jennifer
Swerdlow, Anthony J.
Brenner, Hermann
Wiklund, Fredrik
Bandera, Elisa V.
Siegel, Erin M.
Lester, Jenny
Le, Nhu D.
Taylor, Jack A.
Chan, Andrew T.
Donovan, Jenny L.
Landi, Maria Teresa
Aldrich, Melinda C.
White, Emily
Stevens, Victoria L.
Velez Edwards, Digna R.
Goodman, Marc T.
Easton, Douglas F.
Dwek, Miriam
Berchuck, Andrew
deFazio, Anna
Devilee, Peter
Heitz, Florian
Hopper, John L.
Hunter, David J.
Peters, Ulrike
Albanes, Jeroen R.
Singer, Christian F.
Woll, Penella
Tajara, Eloiza H.
Brunet, Joan
Christiani, David C.
Weitzel, Jeffrey N.
García-Sáenz, José A.
Liloglou, Triantafillos
Phipps, Amanda I.
Cybulski, Cezary
Li, Christopher I.
Lazarus, Philip
Sawyer, Elinor J.
Lane, Jacqueline M.
Meindl, Alfons
Liu, Geoffrey
Grankvist, Kjell
Peters, Wilbert H. M.
Goode, Ellen L.
Godwin, Andrew K.
Butzow, Ralf
Barkardottir, Rosa B.
Bien, Stephanie A.
Ulrich, Cornelia M.
Brunnström, Hans
Goldgar, David E.
Lee, Eunjung
Koutros, Stella
Setiawan, V. Wendy
Fletcher, Olivia
Moysich, Kirsten B.
Høgdall, Estrid
Gallinger, Steven
Lacko, Martin
Chen, Chu
Beckmann, Matthias W.
Elías Aguado-Barrera, Miguel
Barnes, Daniel R.
Imyanitov, Evgeny N.
Clements, Judith
Pandha, Hardev
Lenz, Heinz-Josef
MacInnis, Robert J.
Idos, Gregory
Daly, Mary B.
Anton-Culver, Hoda
Winqvist, Robert
Khusnutdinova, Elza
Muir, Kenneth
Diergaarde, Brenda
Collée, J. Margriet
Rossing, Mary Anne
Radice, Paolo
Bjørge, Line
Phelan, Catherine M.
Usmani, Nawaid
Brook, Mark N.
Rennert, Hedy S.
Lindo, Noralane M.
West, Catharine M. L.
Lam, Stephan
Teare, M. Dawn
Sandler, Dale P.
van Rensburg, Elizabeth J.
Levine, Douglas A.
Milne, Roger L.
Sorensen, Karina Dalsgaard
Sutphen, Rebecca
Miller, Austin
Isaacs, Claudine
Lesse, Davor
Zheng, Wei
Campbell, Peter T.
Olshan, Andrew F.
Modugno, Francesmary
Ramus, Susan J.
James, Paul
Cox, Angela
Caldés, Trinidad
Wang, Qin
Simard, Jacques
Schabath, Matthew B.
Pasaniuc, Bogdan
Carvalho, André L.
Lambrechts, Diether
Antonenkova, Natalia N.
Andrew, Angeline S.
Johansson, Mikael
Johansson, Mattias
Herrero, Rolando
Boccia, Stefania
Håkansson, Niclas
Kjaer, Susanne K.
Berndt, Sonja I.
Lejbkowicz, Flavio
Pharoah, Paul D. P.
Hamilton, Robert J.
Moreno Aguado, Víctor
Gruber, Stephen B.
Gronberg, Henrik
Kristensen, Vessela N.
Sieh, Weiva
Saxena, Richa
Bickeböller, Heike
Joshi, Amit D.
Olah, Edith
Zienolddiny, Shanbeh
Vega, Ana
Gayther, Simon A.
Campbell, Ian
Kühl, Tabea
Hall, Per
Rennert, Gad
Dunning, Alison M.
Czene, Kamila
Stintzing, Sebastian
Osorio, Ana
Hoffmeister, Michael
Spurdle, Amanda B.
Marchand, Loïc Le
Buchanan, Daniel D.
Slattery, Martha L.
Hamann, Ute
Caporaso, Neil E.
Kelemen, Linda E.
Mulligan, Anna Marie
Fortner, Renée T.
Weinstein, Stephanie
Penney, Kathryn L.
Mucci, Lorelei
Jakubowska, Anna
Nikitina-Zake, Liene
Loupakis, Fotios
Van Nieuwenhuysen, Els
Wu, Anna H.
Pashayan, Nora
Risch, Angela
Andrulis, Irene L.
Ganz, Patricia A.
Maier, Christiane
Wu, Xifeng
Khaw, Kay-Tee
Southey, Melissa C.
Townsend, Paul A.
Thomas, Duncan
Vachon, Celine M.
Eccles, Diana
Schmidt, Marjanka K.
Kote-Jarai, Zsofia
Campa, Daniele
Huyghe, Jeroen R.
Duell, Eric J.
Claessens, Frank
May, Taymaa
Houlston, Richard
Fasching, Peter A.
Kim, Jeri
Prokofyeva, Darya
Giles, Graham G.
Karlan, Beth Y.
Lindström, Sara
Antoniou, Antonis C.
Figueiredo, Jane C.
Kiemeney, Lambertus A. L. M.
Eeles, Rosalind A.
Kogevinas, Manolis
Bogdanova, Natalia V.
Guénel, Pascal
Gronwald, Jacek
Brennan, Paul
Batra, Jyotsna
Franceschi, Silvia
Lindblom, Annika
Amos, Christopher I.
Leslie, Goska
Thomassen, Mads
Haiman, Christopher A.
Nussbaum, Robert L.
Benlloch, Sara
Al Olama, Ali Amin
Pring, Miranda
Benitez, Javier
Ziogas, Argyrios
Cancel-Tassin, Géraldine
Price, Alkes L.
Woods, Michael
Tworoger, Shelley S.
Nathanson, Katherine L.
Ellberg, Carolina
Teixeira, Manuel R.
Saloustros, Emmanouil
Tischkowitz, Marc
Zorn, Kristin K.
Plaseska-Karanfilska, Dijana
Newcomb, Polly A.
Keywords: Càncer
Etiologia
Cancer
Etiology
Issue Date: 25-Jan-2019
Publisher: Nature Publishing Group
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4
It is part of: Nature Communications, 2019, vol. 10, p. 431
URI: https://hdl.handle.net/2445/171263
Related resource: https://doi.org/10.1038/s41467-018-08054-4
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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